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Table 4 Results of univariable and multivariable Cox-regression for survival according to dosage reduction

From: Chemotherapy for metastatic colon cancer: No effect on survival when the dose is reduced due to side effects

    95% CI for HR
p value Hazard ratio Lower Upper
Univariable Cox-regression
Dosage reduction No   1.000   
Yes .431 .841 .547 1.294
Multivariable Cox-regression
 Dosage reduction No   1.000   
Yes .600 .861 .492 1.506
 Age continuous .118 .981 .958 1.005
 Sex Male   1.000   
Female .446 1.264 .692 2.310
 T stage T3   1.000   
T4 .229 1.541 .761 3.117
TX .890 .916 .265 3.170
 N stage N0   1.000   
N1 .981 .988 .345 2.824
N2 .713 1.225 .415 3.615
NX .927 .922 .161 5.266
 Grading G2   1.000   
G3 .302 1.354 .761 2.407
GX .458 .576 .134 2.474
 L stage L0   1.000   
L1 .726 1.215 .408 3.620
LX .289 .469 .116 1.901
 V stage V0   1.000   
V1 .872 .920 .334 2.531
VX .164 2.620 .675 10.165
  Charlson Score 6   1.000   
7 .750 .892 .443 1.797
8 .909 .954 .426 2.138
9 .609 1.605 .262 9.822
 Oncological resection/Surgery No   1.000   
Yes .227 .483 .149 1.570
 No of CTX lines continuous .797 1.053 .712 1.556
 Biological CTX No   1.000   
Yes .178 .663 .364 1.207
 CTX regimen FOLFOX- > FOLFIRI   1.000   
FOLFIRI- > FOLFOX .691 1.177 .527 2.627
FOLFOX .001 3.601 1.656 7.827
FOLFIRI .921 .945 .309 2.892