Impact of differences in adenoma and proximal serrated polyp detection rate on the long-term effectiveness of FIT-based colorectal cancer screening

Table 1 Overview of important model parameters

Variable	Base-case analysis		Sensitivity analysis		Reference
FIT-screening					National monitor of the Dutch CRC screening program [29, 34]
Participation FIT	0.73
Adherence to FIT-positive colonoscopy	0.92
Adherence to surveillance colonoscopy	0.92
Primary colonoscopy screening					[27, 29]
Adherence to screening colonoscopy			0.22
Adherence to surveillance colonoscopy			0.92
FIT positivity rate per lesion	Men	Women	Men	Women	[31]
Healthy	0.96^a	0.97^a
Diminutive adenoma	0.004	0.003
Small adenoma	0.12	0.10
Large adenoma	0.30	0.28
Small SP	0.004	0.003	0.06	0.05
Large SP	0.004	0.003	0.30	0.28
Early stage CRC	0.50	0.50
Late stage CRC	0.85	0.85
Contribution of serrated pathway to CRC incidence	15%		30%		[12]
Complications after colonoscopy	0.0028				[35,36,37]
Fatal complications after colonoscopy	0.0001				[35,36,37]

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