Skip to main content

Table 2 Overview of genes related to cholesterol synthesis assessed for differential expression

From: Cholesterol synthesis pathway genes in prostate cancer are transcriptionally downregulated when tissue confounding is minimized

Gene symbol Alternative symbol Gene name Gene function
ACAT1   acetyl-CoA acetyltransferase 1 Synthesis
ACAT2   acetyl-CoA acetyltransferase 2 Synthesis
HMGCS1   3-hydroxy-3-methylglutaryl-CoA synthase 1 Synthesis
HMGCS2   3-hydroxy-3-methylglutaryl-CoA synthase 2 Synthesis
HMGCR   3-hydroxy-3-methylglutaryl-CoA reductase Synthesis (rate limiting enzyme)
MVK   mevalonate kinase Synthesis
PMVK   phosphomevalonate kinase Synthesis
MVD   mevalonate decarboxylase Synthesis
IDI1   isopentenyl-diphosphate delta isomerase 1 Synthesis
IDI2   isopentenyl-diphosphate delta isomerase 2 Synthesis
FDPS   farnesyl diphosphate synthase Synthesis
GGPS1   geranylgeranyl diphosphate synthase 1 Synthesis
FDFT1   farnesyl-diphosphate farnesyltransferase 1 Synthesis
SQLE   squalene epoxidase Synthesis
LSS   lanosterol synthase Synthesis
DHCR24   24-dehydrocholesterol reductase Synthesis
CYP51A1   cytochrome P450 family 51 subfamily A polypeptide 1 Synthesis
TM7SF2   transmembrane 7 superfamily member 2 Synthesis
FAXDC2 C5orf4 fatty acid hydroxylase domain containing 2 Synthesis
MSMO1 SC4MOL methylsterol monooxygenase Synthesis
NSDHL   NAD(P) dependent steroid dehydrogenase-like Synthesis
HSD17B7   hydroxysteroid (17-beta) dehydrogenase 7 Synthesis
EBP   emopamil binding protein (sterol isomerase) Synthesis
SC5D SC5DL sterol-C5-desaturase Synthesis
DHCR7   7-dehydrocholesterol reductase Synthesis (last step before cholesterol)
CEL   carboxyl ester lipase Esterification
LIPA   lipase A, lysosomal acid, cholesterol esterase Esterification
SOAT1   sterol O-acetyltransferase 1 Esterification
SOAT2   sterol O-acetyltransferase 2 Esterification
ABCA1   ATP-binding cassette, sub-family A Efflux
ABCG1   ATP-binding cassette, sub-family G Efflux
SLCO2B1   solute carrier organic anion transporter family member 2B1 Transport
SLCO1B3   solute carrier organic anion transporter family member 1B3 Transport
LDLR   low density lipoprotein receptor Uptake
APOE   apolipoprotein E Component for IDL, HDL and VLDL
SREBF1   sterol binding element transcription factor 1 Transcriptional activation
SREBF2   sterol binding element transcription factor 2 Transcriptional activation (main activator)
SCAP   SREBF chaperone Transcriptional activation
MBTPS1 S1P membrane bound transcription factor peptidase site 1 Transcriptional activation
MBTPS2 S2P membrane bound transcription factor peptidase site 2 Transcriptional activation
INSIG1   insulin induced gene 1 HMGCR degradation
INSIG2   insulin induced gene 2 HMGCR degradation
AMFR GP78 autocrine motility factor receptor E3 ubiquitin protein ligase HMGCR degradation
NR1H3 LXRA nuclear receptor subfamily 1 group H member 3 Transcriptional repression
NR1H2 LXRB nuclear receptor subfamily 1 group H member 2 Transcriptional repression
RXRA   retinoid X receptor alpha Transcriptional repression
RXRB   retinoid X receptor beta Transcriptional repression
MYLIP IDOL myosin regulatory light chain interacting protein Degradation of LDLR