|
ACAT1
| |
acetyl-CoA acetyltransferase 1
|
Synthesis
|
|
ACAT2
| |
acetyl-CoA acetyltransferase 2
|
Synthesis
|
|
HMGCS1
| |
3-hydroxy-3-methylglutaryl-CoA synthase 1
|
Synthesis
|
|
HMGCS2
| |
3-hydroxy-3-methylglutaryl-CoA synthase 2
|
Synthesis
|
|
HMGCR
| |
3-hydroxy-3-methylglutaryl-CoA reductase
|
Synthesis (rate limiting enzyme)
|
|
MVK
| |
mevalonate kinase
|
Synthesis
|
|
PMVK
| |
phosphomevalonate kinase
|
Synthesis
|
|
MVD
| |
mevalonate decarboxylase
|
Synthesis
|
|
IDI1
| |
isopentenyl-diphosphate delta isomerase 1
|
Synthesis
|
|
IDI2
| |
isopentenyl-diphosphate delta isomerase 2
|
Synthesis
|
|
FDPS
| |
farnesyl diphosphate synthase
|
Synthesis
|
|
GGPS1
| |
geranylgeranyl diphosphate synthase 1
|
Synthesis
|
|
FDFT1
| |
farnesyl-diphosphate farnesyltransferase 1
|
Synthesis
|
|
SQLE
| |
squalene epoxidase
|
Synthesis
|
|
LSS
| |
lanosterol synthase
|
Synthesis
|
|
DHCR24
| |
24-dehydrocholesterol reductase
|
Synthesis
|
|
CYP51A1
| |
cytochrome P450 family 51 subfamily A polypeptide 1
|
Synthesis
|
|
TM7SF2
| |
transmembrane 7 superfamily member 2
|
Synthesis
|
|
FAXDC2
|
C5orf4
|
fatty acid hydroxylase domain containing 2
|
Synthesis
|
|
MSMO1
|
SC4MOL
|
methylsterol monooxygenase
|
Synthesis
|
|
NSDHL
| |
NAD(P) dependent steroid dehydrogenase-like
|
Synthesis
|
|
HSD17B7
| |
hydroxysteroid (17-beta) dehydrogenase 7
|
Synthesis
|
|
EBP
| |
emopamil binding protein (sterol isomerase)
|
Synthesis
|
|
SC5D
|
SC5DL
|
sterol-C5-desaturase
|
Synthesis
|
|
DHCR7
| |
7-dehydrocholesterol reductase
|
Synthesis (last step before cholesterol)
|
|
CEL
| |
carboxyl ester lipase
|
Esterification
|
|
LIPA
| |
lipase A, lysosomal acid, cholesterol esterase
|
Esterification
|
|
SOAT1
| |
sterol O-acetyltransferase 1
|
Esterification
|
|
SOAT2
| |
sterol O-acetyltransferase 2
|
Esterification
|
|
ABCA1
| |
ATP-binding cassette, sub-family A
|
Efflux
|
|
ABCG1
| |
ATP-binding cassette, sub-family G
|
Efflux
|
|
SLCO2B1
| |
solute carrier organic anion transporter family member 2B1
|
Transport
|
|
SLCO1B3
| |
solute carrier organic anion transporter family member 1B3
|
Transport
|
|
LDLR
| |
low density lipoprotein receptor
|
Uptake
|
|
APOE
| |
apolipoprotein E
|
Component for IDL, HDL and VLDL
|
|
SREBF1
| |
sterol binding element transcription factor 1
|
Transcriptional activation
|
|
SREBF2
| |
sterol binding element transcription factor 2
|
Transcriptional activation (main activator)
|
|
SCAP
| |
SREBF chaperone
|
Transcriptional activation
|
|
MBTPS1
|
S1P
|
membrane bound transcription factor peptidase site 1
|
Transcriptional activation
|
|
MBTPS2
|
S2P
|
membrane bound transcription factor peptidase site 2
|
Transcriptional activation
|
|
INSIG1
| |
insulin induced gene 1
|
HMGCR degradation
|
|
INSIG2
| |
insulin induced gene 2
|
HMGCR degradation
|
|
AMFR
|
GP78
|
autocrine motility factor receptor E3 ubiquitin protein ligase
|
HMGCR degradation
|
|
NR1H3
|
LXRA
|
nuclear receptor subfamily 1 group H member 3
|
Transcriptional repression
|
|
NR1H2
|
LXRB
|
nuclear receptor subfamily 1 group H member 2
|
Transcriptional repression
|
|
RXRA
| |
retinoid X receptor alpha
|
Transcriptional repression
|
|
RXRB
| |
retinoid X receptor beta
|
Transcriptional repression
|
|
MYLIP
|
IDOL
|
myosin regulatory light chain interacting protein
|
Degradation of LDLR
|
