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Fig. 1 | BMC Cancer

Fig. 1

From: microRNA-451a regulates colorectal cancer proliferation in response to radiation

Fig. 1

miR-451a is robustly induced by radiation in human and mouse colorectal carcinoma. a Design of the screen for miRs induced by radiation. Heatmap depicts miRs with more than 2 fold change from the affymetrix microRNA array v4.0 across both tumor types. b Levels of the two most upregulated and downregulated miRs 6 h post 2 Gy radiation were validated by qRT-PCR using specific Taqman probes for each microRNA. Mean fold change after normalization to a housekeeping RNA, RNU48, is depicted. c Most abundant (> 10 counts) miRs in CT26 mouse colorectal carcinomas at 6 h post 10 Gy treatment. Bars represent mean + SD of 3 mice in 0 Gy group and 2 mice in 10 Gy group. RNA was extracted from tumors and miR profiles were analyzed using the Nanostring miR panel

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