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Table 1 Baseline characteristics of patients scheduled for PIPAC/PITAC

From: Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) for the treatment of malignant mesothelioma

Characteristics/Data items

Number

Percent

Total patients

29

100

Sex

 - Male

17

58.6

 - Female

12

41.4

Mean age (years; range)

62.4 (42 to 84)

 

ECOG performance score

 - 0 or 1

26

89.7

 - 2 or 3

3

10.3

Karnofsky Index

 - 100%

2

6.9

 - 90%

15

51.7

 - 80%

9

31.0

 - 70%

2

6.9

 - 60%

1

3.4

Mesothelioma cell type

 - epithelioid

29

100

Clinical type

 - “dry” type

8

27.6

 - “wet” type

12

41.4

 - “mixed” type

9

31.0

Alcohol consumption

 - no or minimal

22

75.9

 - daily alcohol intake

7

24.1

Smoking habits

 - no

18

62.0

 - yes

11

38.0

Primary tumor site at initial diagnosis

 - abdominal

24

82.8

 - thoracal

5

17.2

Prior extended resection surgery

 - cytoreduction & HIPEC (CC-0 & CC-1)

7

24.1

 - abdominal debulking

8

27.6

 - pleuropneumonectomy

2

6.9

 - thoracotomy/decortication

3

10.3

Prior surgical score (PSS)

 - PSS 0

11

27.5

 - PSS 1

8

29

 - PSS 2

6

15

 - PSS 3

15

37.5

Extra-abdominal metastatic spread before PIPAC/PITAC

13

44.8

 - thoracal

8

27.6

 - mediastinal

3

10.3

 - abdominal wall

2

6.9

No previous systemic chemotherapy

8

27.6

 - refused any systemic chemotherapy

3

10.3

 - stop due to severe side effects

3

10.3

 - new diagnosis of disease

2

6.9

First line chemotherapy

21

72.4

 - Cisplatin & Pemetrexed

17

58.6

 - Pemetrexed mono

3

10.3

 - Carboplatin & Pemetrexed

1

3.4

Second line chemotherapy

8

27.6

 - Cisplatin & Pemetrexed

5

17.2

 - Pemetrexed mono

3

10.3

Third line chemotherapy

2

6.9

 - Pemetrexed mono

2

6.9

Systemic chemotherapy & scheduled for PIPAC

7

24.1

 - Cisplatin & Pemetrexed

4

13.8

 - Pemetrexed mono

3

10.3

Scheduled for PIPAC without systemic chemotherapy

22

75.9

  1. HIPEC hyperthermic intraperitoneal chemotherapy, ECOG Eastern Conference Oncology Study Group, PIPAC Pressurized IntraPeritoneal Aerosol Chemotherapy, PITAC Pressurized IntraThoracal Aerosol Chemotherapy, PSS prior surgical score, “wet” type = presence of ascites, “dry” = type absence of ascites