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Table 5 Associations between dietary patterns and lung cancer risk by genotype at 3 SNPs

From: Dietary patterns, BCMO1 polymorphisms, and primary lung cancer risk in a Han Chinese population: a case-control study in Southeast China

Dietary patterns

Cases/controls

Adjusted OR (95% CI)

Cases/controls

Adjusted OR (95% CI)

P for interaction

rs6564851:GG

rs6564851:GT + TT

High quality protein

P trend  = 0.655

 

P trend  = 0.001

0.019

 Q1(low)

186/169

1.00(ref)

80/111

1.00(ref)

 

 Q2

195/180

1.112 (0.807–1.531)

76/99

1.186 (0.758–1.855)

 

 Q3

176/184

0.999 (0.722–1.381)

97/82

1.869 (1.200–2.910)

 

 Q4(high)

186/191

1.120 (0.811–1.547)

98/86

1.870 (1.206–2.900)

 

Fruits and vegetables

P trend  < 0.001

 

P trend  < 0.001

0.792

 Q1(low)

386/186

1.00(ref)

181/91

1.00(ref)

 

 Q2

162/182

0.413 (0.304–0.559)

82/94

0.511 (0.339–0.770)

 

 Q3

114/176

0.300 (0.216–0.416)

53/99

0.280 (0.179–0.437)

 

 Q4(high)

81/180

0.217 (0.153–0.309)

38/94

0.227 (0.140–0.367)

 

Cereals and meat

P trend  = 0.036

 

P trend  = 0.541

0.1

 Q1(low)

188/165

1.00(ref)

89/119

1.00(ref)

 

 Q2

203/191

0.857 (0.622–1.181)

91/85

1.230 (0.797–1.899)

 

 Q3

170/185

0.726 (0.523–1.008)

92/89

1.163 (0.757–1.787)

 

 Q4(high)

182/183

0.729 (0.525–1.012)

82/85

1.163 (0.748–1.809)

 

Frugal pattern

P trend  = 0.028

 

P trend  = 0.445

0.371

 Q1(low)

165/192

1.00(ref)

83/86

1.00(ref)

 

 Q2

173/183

1.016 (0.734–1.408)

59/95

0.569 (0.354–0.915)

 

 Q3

174/176

1.053 (0.759–1.461)

85/93

0.785 (0.499–1.234)

 

 Q4(high)

231/173

1.423 (1.036–1.956)

127/104

1.034 (0.672–1.592)

 
 

rs12934922:AA

rs12934922:AT+TT

 

High quality protein

P trend  = 0.065

 

P trend  = 0.119

0.69

 Q1(low)

203/213

1.00(ref)

65/79

1.00(ref)

 

 Q2

209/221

1.132 (0.844–1.519)

72/64

1.400 (0.838–2.339)

 

 Q3

203/214

1.180 (0.877–1.588)

78/67

1.610 (0.965–2.686)

 

 Q4(high)

224/213

1.321 (0.984–1.773)

67/75

1.470 (0.878–2.463)

 

Fruits and vegetables

P trend  < 0.001

 

P trend  < 0.001

0.447

 Q1(low)

426/214

1.00(ref)

156/73

1.00(ref)

 

 Q2

185/227

0.430 (0.326–0.567)

59/65

0.432 (0.266–0.701)

 

 Q3

135/210

0.309 (0.229–0.416)

38/74

0.263 (0.156–0.443)

 

 Q4(high)

93/210

0.224 (0.162–0.309)

29/73

0.216 (0.124–0.376)

 

Cereals and meat

P trend  = 0.701

 

P trend  = 0.035

0.129

 Q1(low)

206/216

1.00(ref)

77/74

1.00(ref)

 

 Q2

217/226

0.903 (0.674–1.210)

82/59

1.275 (0.767–2.118)

 

 Q3

200/212

0.864 (0.641–1.164)

68/77

0.836 (0.510–1.370)

 

 Q4(high)

216/207

0.953 (0.707–1.283)

55/75

0.624 (0.369–1.053)

 

Frugal pattern

P trend  = 0.079

 

P trend  = 0.725

0.619

 Q1(low)

179/217

1.00(ref)

72/66

1.00(ref)

 

 Q2

191/223

0.933 (0.689–1.263)

55/69

0.701 (0.412–1.193)

 

 Q3

1194/207

0.938 (0.691–1.273)

71/77

0.821 (0.492–1.368)

 

 Q4(high)

275/214

1.287 (0.960–1.727)

84/73

1.031 (0.627–1.695)

 
 

rs7501331:CC

rs7501331:CT + TT

 

High quality protein

P trend  = 0.097

 

P trend  = 0.134

0.902

 Q1(low)

180/181

1.00(ref)

77/89

1.00(ref)

 

 Q2

172/177

1.139 (0.826–1.571)

92/101

1.189 (0.751–1.883)

 

 Q3

182/168

1.323 (0.957–1.827)

81/95

1.089 (0.678–1.748)

 

 Q4(high)

173/170

1.269 (0.917–1.756)

103/103

1.483 (0.934–2.354)

 

Fruits and vegetables

P trend  < 0.001

 

P trend  < 0.001

0.487

 Q1(low)

359/173

1.00(ref)

191/101

1.00(ref)

 

 Q2

160/175

0.464 (0.341–0.630)

65/99

0.372 (0.241–0.574)

 

 Q3

115/182

0.291 (0.210–0.402)

51/86

0.332 (0.209–0.528)

 

 Q4(high)

73/166

0.212 (0.147–0.305)

46/102

0.274 (0.172–0.435)

 

Cereals and meat

P trend  = 0.110

 

P trend  = 0.948

0.44

 Q1(low)

169/177

1.00(ref)

100/102

1.00(ref)

 

 Q2

202/179

1.083 (0.786–1.494)

77/89

0.778 (0.493–1.229)

 

 Q3

176/166

1.005 (0.725–1.395)

84/104

0.694 (0.443–1.088)

 

 Q4(high)

160/174

0.769 (0.550–1.074)

92/93

1.032 (0.662–1.610)

 

Frugal pattern

P trend  = 0.014

 

P trend  = 0.727

0.253

 Q1(low)

150/180

1.00(ref)

88/92

1.00(ref)

 

 Q2

153/175

0.979 (0.700–1.370)

76/100

0.709 (0.446–1.127)

 

 Q3

180/170

1.172 (0.842–1.630)

71/95

0.651 (0.405–1.048)

 

 Q4(high)

224/171

1.433 (1.036–1.982)

118/101

1.055 (0.682–1.632)