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Table 3 Logistic regression analysis of the associations of the H2AFX and MRE11 SNPs with BC

From: Genetic variants in ATM, H2AFX and MRE11 genes and susceptibility to breast cancer in the polish population

SNP

Genotypes No. (%)

P value

OR

95% CI

C

BC

H2AFX

rs7759

 AA

263(51)

117 (37)

 

1a

 

 AG

217 (42.1)

167 (53.2)

0.0003 (0.0024) b

1.73

1.28 to 2.33

 GG

36 (6.9)

31 (9.8)

0.013 (0.042) b

1.94

1.14 to 3.28

 AG + GG

253 (49)

198 (63)

0.0001 (0.0016) b

1.76

1.32 to 2.34

rs8551

 CC

220 (42.7)

111 (35.3)

 

1a

 

 CT

235 (45.7)

149 (47.2)

0.14

1.26

0.93 to 1.71

 TT

60 (11.6)

55 (17.5)

0.0063 (0.034) b

1.82

1.18 to 2.80

 CT + TT

295 (57.3)

204 (64.7)

0.03

1.37

1.03 to 1.83

rs643788

 TT

228(44.4)

142 (45)

 

1a

 

 TC

216 (42)

118 (37.5)

0.40

0.88

0.65 to 1.19

 CC

71 (13.6)

55 (17.6)

0.29

1.24

0.83 to 1.87

 TC + CC

287 (55.7)

173 (55.1)

0.82

0.96

0.73 to 1.28

rs2509049

 CC

218 (42.3)

113 (35.9)

 

1a

 

 CT

237 (46)

147 (46.8)

0.25

1.19

0.88 to 1.62

 TT

60 (11.7)

55 (17.3)

0.009 (0.036) b

1.77

1.14 to 2.72

 CT + TT

297 (58.6)

202 (64.1)

0.06

1.31

0.98 to 1.75

MRE11

rs1061956

 AA

506 (98.2)

312 (99)

 

1a

 

 AG

9 (1.8)

3 (1)

0.35

0.54

0.15 to 2.01

rs2155209

 TT

247 (48)

149 (47.4)

 

1a

 

 TC

223 (43.2)

129 (41)

0.78

0.96

0.71 to 1.29

 CC

45 (8.8)

37 (11.6)

0.21

1.36

0.84 to 2.20

 CC + TC

268 (52)

166 (52.6)

0.85

1.03

0.78 to 1.36

  1. a = reference category; OR (95% CI) = odds ratio (95% confidence interval); b = result statistically significant after Benjamini-Hochberg correction; C = controls, BC = breast cancer patients
  2. Bold data are statistically significant