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Fig. 5 | BMC Cancer

Fig. 5

From: ZBP-89 and Sp1 contribute to Bak expression in hepatocellular carcinoma cells

Fig. 5

ZBP-89 and Sp1 regulated Bak expression cooperatively. Western blotting data showed that overexpressed ZBP-89 induced Bak expression, while its siRNA treatment reduced Bak expression (A and B, lane 6, * p < 0.05 compared control). Blocking ZBP-89 expression decreased Bak level even in the presence of MMA treatment, meanwhile, ZBP-89 siRNA could also abolished Sp1 overexpression mediated Bak up-regulation (a and b, lane 8, * p < 0.05 compared control). In RT-PCR experiment of Bak mRNA semi-quantification experiment, the findings in Fig. A were confirmed (C, * p < 0.05 compared control, 4-well repeated in triple experiments, data shown as Mean ± SE)

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