Fig. 6

Genes involved in drug metabolism of one therapy may be the target of another therapy. High drug metabolism gene expression in BRCA was protective. This is the opposite association as expected and observed in other cancer types. The upper panel shows the survival association with high expression levels of drug metabolizing genes in BRCA, across a series of threshold values. Analogous data for UCEC is shown below, for comparison. We believe this association can be explained by interactions between the molecular mechanisms of cytotoxic therapies and anti-hormone therapies; see Discussion