Fig. 3

Our Therapy Efficacy model identified high-risk patients who received therapies with specific PK mechanisms activated within their tumors. a We first plot the Kaplan-Meyer survival curves of the pan-cancer cohort classified by our genomics-based efficacy model based on high expression of the exporters or metabolizers of the drugs administered. Shaded bands indicate 95% confidence intervals. Analogous per-cancer survival curves are shown for (b) KIRC and (d) OV. In this retrospective study, cohorts were not balanced with respect to disease state or clinical characteristics (Additional file 1: Figure S1). Thus, we plot survival curves adjusted to a uniform cohort of 50 year olds with stage-3 grade-3 (c) KIRC or (e) OV. Analogous plots are shown for all cancer types in Additional file 1: Figure S3. We assessed statistical significance using Cox regression with results shown in Table 3 and Figs. 4, 5 and 6