Fig. 1

Human tumors may up- or down-regulate PK genes. Each gene was scored relative to a composite-normal reference to generate conservative estimates of aberrant somatic gene expression. RSEM normalized gene expression data were used. The expression score of each gene in each tumor sample is the signed Z-score relative to normal tissue samples. Example probability density distributions of gene expression for two genes are shown: (Left) drug importer SLC16A2 and (Right) drug exporter ABCC5