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Table 4 Diagnostic value of the gas chromatography/mass spectrometry analysis with multivariate statistical analysis methods

From: Serum microRNA signatures and metabolomics have high diagnostic value in gastric cancer

Statistical method Number of components Sensitivity (%) Specificity (%) AUC (95% CI) Youden index Cumulative variance
PCA 11 100.0 100.0 1.000 (1.000, 1.000) 1.000 0.445
10 100.0 100.0 1.000 (1.000, 1.000) 1.000 0.379
9 100.0 100.0 1.000 (1.000, 1.000) 1.000 0.195
8 100.0 100.0 1.000 (1.000, 1.000) 1.000 0.153
7 100.0 100.0 1.000 (1.000, 1.000) 1.000 0.127
6 92.0 96.7 0.984 (0.960, 1.000) 0.887 0.120
5 92.0 93.3 0.980 (0.952, 1.000) 0.853 0.086
4 88.0 96.7 0.976 (0.945, 1.000) 0.847 0.070
3 92.0 86.7 0.964 (0.924, 1.000) 0.787 0.047
2 84.0 93.3 0.959 (0.915, 1.000) 0.773 0.039
1 80.0 63.3 0.707 (0.567, 0.846) 0.433 0.035
PLS 5 100.0 100.0 1.000 (1.000, 1.000) 1.000 0.812
4 100.0 100.0 1.000 (1.000, 1.000) 1.000 0.791
3 100.0 100.0 1.000 (1.000, 1.000) 1.000 0.690
2 92.0 100.0 0.991 (0.974, 1.000) 0.920 0.582
1 100.0 90.0 0.956 (0.895, 1.000) 0.900 0.501
OPLS 1 100.0 100.0 1.000 (1.000, 1.000) 1.000 0.853
  1. Abbreviations: AUC area under the curve, CI confidence interval, PCA principal component analysis, PLS-DA partial least squares-discriminate analysis, OPLS-DA orthogonal partial least squares-discriminant analysis
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