Table 4 Diagnostic value of the gas chromatography/mass spectrometry analysis with multivariate statistical analysis methods
From: Serum microRNA signatures and metabolomics have high diagnostic value in gastric cancer
Statistical method | Number of components | Sensitivity (%) | Specificity (%) | AUC (95% CI) | Youden index | Cumulative variance |
|---|---|---|---|---|---|---|
PCA | 11 | 100.0 | 100.0 | 1.000 (1.000, 1.000) | 1.000 | 0.445 |
10 | 100.0 | 100.0 | 1.000 (1.000, 1.000) | 1.000 | 0.379 | |
9 | 100.0 | 100.0 | 1.000 (1.000, 1.000) | 1.000 | 0.195 | |
8 | 100.0 | 100.0 | 1.000 (1.000, 1.000) | 1.000 | 0.153 | |
7 | 100.0 | 100.0 | 1.000 (1.000, 1.000) | 1.000 | 0.127 | |
6 | 92.0 | 96.7 | 0.984 (0.960, 1.000) | 0.887 | 0.120 | |
5 | 92.0 | 93.3 | 0.980 (0.952, 1.000) | 0.853 | 0.086 | |
4 | 88.0 | 96.7 | 0.976 (0.945, 1.000) | 0.847 | 0.070 | |
3 | 92.0 | 86.7 | 0.964 (0.924, 1.000) | 0.787 | 0.047 | |
2 | 84.0 | 93.3 | 0.959 (0.915, 1.000) | 0.773 | 0.039 | |
1 | 80.0 | 63.3 | 0.707 (0.567, 0.846) | 0.433 | 0.035 | |
PLS | 5 | 100.0 | 100.0 | 1.000 (1.000, 1.000) | 1.000 | 0.812 |
4 | 100.0 | 100.0 | 1.000 (1.000, 1.000) | 1.000 | 0.791 | |
3 | 100.0 | 100.0 | 1.000 (1.000, 1.000) | 1.000 | 0.690 | |
2 | 92.0 | 100.0 | 0.991 (0.974, 1.000) | 0.920 | 0.582 | |
1 | 100.0 | 90.0 | 0.956 (0.895, 1.000) | 0.900 | 0.501 | |
OPLS | 1 | 100.0 | 100.0 | 1.000 (1.000, 1.000) | 1.000 | 0.853 |