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Table 6 Uni- and multivariate Hazard Cox regression analysis of recurrence-free survival considering the dichotomized tumor expression in recurrent cancer biopsies

From: High OX40 expression in recurrent ovarian carcinoma is indicative for response to repeated chemotherapy

 

Univariate

Multivariate

HR

95% CI

p-values

HR

95% CI

p-values

Age

1.00

0.97 - 1.03

0.888

1.00

0.97 - 1.03

0.819

OX40high vs OX40low

0.39

0.16 - 0.94

0.036

0.74

0.18 - 3.01

0.676

Residual disease < 2 cm

1.13

0.56 - 2.28

0.724

0.88

0.40 - 1.91

0.747

Residual disease > 2 cm

3.67

1.62 - 8.31

0.002

2.78

1.09 - 7.06

0.032

No. of chemotherapy cycles

1.28

1.05 - 1.55

0.013

1.12

0.82 - 1.53

0.477

FIGO IIIA

0.34

0.02 - 5.72

0.455

0.43

0.02 - 8.31

0.573

FIGO IIIB

0.93

0.11 - 8.04

0.944

0.90

0.10 - 8.17

0.928

FIGO IIIC

1.21

0.16 - 9.03

0.851

1.02

0.13 - 8.24

0.985

FIGO IV

1.48

0.18 - 11.94

0.712

0.99

0.11 - 9.00

0.991

  1. Multivariate analyses showing Hazard Ratios and p-value for all recurrent cancer biopsies (n = 43 less than 44 due to missing value) conferred by categorized OX40 expression, age, residual disease after cytoreductive surgery, number of chemotherapy cycles and FIGO classification