Table 4 Significant correlations of ZG16 copy number and colon cancer (TCGA COAD dataset)
From: Loss of ZG16 is associated with molecular and clinicopathological phenotypes of colorectal cancer
Clinical-pathological features | Number of cases | Copy number (Average) | P | |
|---|---|---|---|---|
Colon polyps present | ||||
yes | 80 | 0.0309 | 0.031 | |
no | 148 | 0.0778 | ||
Anatomic neoplasm subdivision | ||||
ascending colon | 86 | 0.108 | 0.028 | |
descending colon | 20 | 0.378 | ||
Histological type | ||||
adenocarcinoma | 62 | 0.07 | 0.006 | |
mucinous- adenocarcinoma | 385 | −0.015 | ||
Hyper-mutation status | ||||
TRUE | 32 | −0.012 | 0 | |
FALSE | 121 | 0.0972 | ||
Microsatellite instability status | ||||
MSI-H | 25 | −0.0234 | 0.003 | |
MSI-L | 25 | 0.0657 | ||
MSS | 100 | 0.101 | ||
MLH1 silencing | ||||
yes | 20 | −0.0227 | 2.39E-09 | |
no | 121 | 0.0952 | ||
CpG island methylator phenotype | ||||
CIMP-H | 31 | 0.011 | 0.01 | |
CIMP-L | 32 | 0.084 | ||
Treatment success status | ||||
complete remission | 178 | 0.077 | 0.046 | |
progressive | 36 | 0.172 | ||