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Table 2 Correlations of ZG16 expression with clinicopathological features of colorectal cancer (TCGA COAD dataset)

From: Loss of ZG16 is associated with molecular and clinicopathological phenotypes of colorectal cancer

Clinical-pathological features

Number of cases

Gene expression (average)

P

Gender

 

male

94

0.512

0.037

 

female

99

− 0.487

 

Colon polyps present

 

yes

73

−0.768

0.246

 

no

129

−1.109

 

Anatomic neoplasm subdivision

 

ascending colon

86

0.499

0.020

 

descending colon

20

1.681

 

Histological type

 

adenocarcinoma

62

−0.98

0.244

 

mucinous- adenocarcinoma

385

−0.41

 

Lymphatic invasion

 

yes

77

−1.136

0.793

 

no

175

−1.032

 

Pathological-N

N2 N0

48,167

− 1.464 -0.806

0.0072

Hyper-mutation status

 

true

32

−1.23

0.018

 

false

119

0.571

 

Microsatellite instability status

 

MSI-H

25

−1.58

0.037

 

MSI-L

25

1.13

 
 

MSS

98

0.491

 

MLH1 silencing

 

yes

20

−1.143

0.043

 

no

120

0.563

 

CpG island methylator phenotype

 

CIMP-H

29

−0.74

0.38

 

CIMP-L

35

−0.24

 

Treatment success status

 

complete remission

92

−0.49

0.080

 

progressive

28

−1.91

 

Sample type

 

primary tumor

286

−1.61

0.000

 

tissue normal

46

14.59