Vemurafenib (N = 20) | |||
---|---|---|---|
Study day | Parameter | Mean ± SD | CV % |
Day 1 | AUC0-8h, μg·h/mL | 37.5 ± 22.3 | 59.4 |
AUC0-12h, μg·h/mL | 57.5 ± 32.6 | 56.7 | |
Cmax, μg/mL | 6.9 ± 3.9 | 55.8 | |
Day 15 | Ctrough, μg/mL | 63.0 ± 23.3 | 37.0 |
Day 21 | AUC0-8h, μg·h/mL | 501.3 ± 123.0 | 24.5 |
AUC0-12h, μg·h/mL | 720.3 ± 185.8 | 25.8 | |
Cmax, μg/mL | 77.6 ± 17.9 | 23.0 | |
Ctrough, μg/mL | 72.6 ± 20.0 | 27.5 | |
t½, h | 35.6 ± 18.1 | – | |
Accumulation ratio | 17.9 ± 14.1 | – |