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Table 5 Cox univariate analysis for overall survival, with a time dependency added to CYFRA 21-1 pre-treatment and post-treatment levels

From: Prognostic value of serum CYFRA 21-1 1 in patients with anal canal squamous cell carcinoma treated with radio(chemo)therapy

  Univariate analysis
HR [95%CI] p
Age at diagnosis (> vs. ≤ 65 years) 2.13 [0.81;5.61] 0.12
Gender (male/female) 0.52 [0.16;3.07] 0.30
T stage (T3/T4 vs. T1/T2) 5.44 [1.36;16.48] 0.007
Nodal status (positive/negative) 1.34 [0.49;3.63] 0.56
Clinical stage (IIIA/IIIB vs. I/II) 2.72 [0.78;9.46] 0.12
Chemotherapy associated with radiation therapy (yes/no) 0.79 [0.28;2.27] 0.67
CYFRA 21-1 levels (elevated /normal)
Pre-treatment 5.99 [0.80;45.22] 0.08
Post-treatment 4.05 [1.49;10.95] 0.006