Skip to main content

Table 3 Relative risks (RRs) and 95% confidence intervals (CIs) of recurrence (R+), lymph node involvement (LN+), lymphovascular space invasion (LVSI+), and myometrial invasion over 50% (MI > 50%) in patients with DFF40*-, DFF45**-, and BCL2***-negative endometrial cancers

From: Non-endometrioid and high-grade endometrioid endometrial cancers show DNA fragmentation factor 40 (DFF40) and B-cell lymphoma 2 protein (BCL2) underexpression, which predicts disease-free and overall survival, but not DNA fragmentation factor 45 (DFF45) underexpression

  Low and moderate-grade endometroid cancer (Group A) Non-endometrioid and high-grade endometroid endometrial cancer (Group B) Total cohort
R+
 DFF40* 1.611 (CI:0.694-3.741; p = 0.267) 7.423 (CI: 1.048-52.599; p = 0.046) 2.435 (CI: 1.365-4.343; p = 0.002)
 DFF45** 0.892 (CI:0.222-3.581; p = 0.871) 1.843 (CI: 0.608-5.586; p = 0.280) 1.211 (CI:0.506-2.898; p = 0.668)
 BCL-2*** 2.048 (CI: 0.821-5.081; p = 0.121) 12.847 (CI: 1.805-91.464; p = 0.012) 4.192 (CI: 2.128-8.261; p < 0.001)
LN+
 DFF40* 1.033 (CI:0.567-1.766; p = 0.915) 7.422 (CI:1.048-52.594; p = 0.045) 4.19 (CI: 1.88-9.33; p < 0.001)
 DFF45** 0.433 (CI:0.133-1.412; p = 0.166) 1.161 (CI: 0.441-3.060; p = 0.763) 0.70 (CI: 0.33-1.48; p = 0.344)
 BCL-2*** 3.386 (CI:1.256-9.127; p = 0.015) 3.624 (CI:1.493-11.424; p-0.028) 4.36 (CI: 2.14-8.87; p < 0.001)
LVSI+
 DFF40* 0.947 (CI: 0.508-1.767; p = 0.865) 2907 (CI: 1.273-6.641; p = 0.011) 1.953 (CI:1.360-2.803;p < 0.001)
 DFF45** 0.844 (CI: 0.374-1.907; p = 0.684) 1.736 (CI: 0.846-3.563; p = 0.133) 1.378 (CI: 0.749-2.537; p = 0.303)
 BCL-2*** 2.483 (CI: 1.459-4.226; p < 0.001) 3.624 (CI:1.493-11.424; p-0.028) 3.089 (CI:2.075-4.599; p < 0.001)
MI > 50%
 DFF40* 1.058 (CI: 0.873-1.283; p = 0.562) 1.183 (CI:0.962-1.456; p = 0.112) 1.216 (CI: 1.078-1.270; p = 0.001)
 DFF45** 1.057 (CI: 0.668-1.672; p = 0.812) 1.189 (CI: 0.895-1.580; p = 0.233) 1.086 (CI: 0.888-1.328; p = 0.422)
 BCL-2*** 1.335 (CI: 1.332-1.574; p < 0.001) 1.073 (CI: 0.920-1.251; p = 0.369) 1.549 (CI: 1.346-1.782; p < 0.001)
  1. *DFF40 - DNA fragmentation factor 40; **DFF45 - DNA fragmentation factor 45; ***BCL2 - B-cell lymphoma 2