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Table 2 Immunoexpression of DFF40*, DFF45**, and BCL2*** in endometrial cancers in relation to histological type and study groups A and B

From: Non-endometrioid and high-grade endometrioid endometrial cancers show DNA fragmentation factor 40 (DFF40) and B-cell lymphoma 2 protein (BCL2) underexpression, which predicts disease-free and overall survival, but not DNA fragmentation factor 45 (DFF45) underexpression

  Low and moderate-grade endometroid cancer (Group A) pA Non-endometrioid and high-grade endometroid endometrial cancer (Group B) pB
Tumor histology EAC-G1$
N = 90
EAC-G2$$
N = 125
Carcinosarcomas
N = 31
Serosus tumor
N = 22
Clear cell tuor
N = 25
EAC-G3$$$
N = 49
DFF40*
 High 31 (34.44%) 28 (22.40%) 0.143 5 (16.13%) 2 (9.09%) 1 (4.00%) 4 (8.16%) 0.754
 Low 33 (36.67%) 52 (41.60%) 6 (19.35%) 3 (13.64%) 6 (24.00%) 11 (22.45%)
 Negative 26 (28.89%) 45 (36.00%) 20 (64.52%) 17 (77.27%) 18 (72.00%) 34 (69.39%)
pAB < 0.001#
DFF45**
 High 1 (1.11%) 0 (0.00%) 0.409 1 (3.22%) 0 (0.00%) 0 (0.00%) 2 (4.08%) 0.935
 Low 7 (7.78%) 13 (10.40%) 3 (9.68%) 2 (9.09%) 3 (12.00%) 10 (20.41%)
 Negative 82 (9.11%) 112 (89.6%) 27 (87.10%) 20 (90.91%) 22 (88.00%) 37 (75.51%)
pAB = 0.101
Bcl-2***
 High 29 (32.22%) 44 (35.20%) 0.523 2 (6.45%) 1 (4.55%) 1 (4.00%) 5 (10.21%) 0.187
4 (12.90%) 4 (18.18%) 3 (12.00%)
 Low 34 (37.78%) 38 (30.40%) 16 (32.65%)
 Negative 27 (30.00%) 43 (34.40%) 25 (80.65%) 17 (77.27%) 21 (84.00%) 28 (57.14%)
pAB < 0.001#
  1. pA – chi-squared test in Group A; pB – chi-squared test in Group B; pAB – chi-squared test between Group A and Group B; $endometrial adenocarcinoma grade 1; $$endometrial adenocarcinoma grade 2; $$$endometrial adenocarcinoma grade 3; *DFF40 – DNA fragmentation factor 40; **DFF45 – DNA fragmentation factor 45; ***BCL2 – B-cell lymphoma 2