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Table 2 Immunoexpression of DFF40*, DFF45**, and BCL2*** in endometrial cancers in relation to histological type and study groups A and B

From: Non-endometrioid and high-grade endometrioid endometrial cancers show DNA fragmentation factor 40 (DFF40) and B-cell lymphoma 2 protein (BCL2) underexpression, which predicts disease-free and overall survival, but not DNA fragmentation factor 45 (DFF45) underexpression

 

Low and moderate-grade endometroid cancer (Group A)

pA

Non-endometrioid and high-grade endometroid endometrial cancer (Group B)

pB

Tumor histology

EAC-G1$

N = 90

EAC-G2$$

N = 125

Carcinosarcomas

N = 31

Serosus tumor

N = 22

Clear cell tuor

N = 25

EAC-G3$$$

N = 49

DFF40*

 High

31 (34.44%)

28 (22.40%)

0.143

5 (16.13%)

2 (9.09%)

1 (4.00%)

4 (8.16%)

0.754

 Low

33 (36.67%)

52 (41.60%)

6 (19.35%)

3 (13.64%)

6 (24.00%)

11 (22.45%)

 Negative

26 (28.89%)

45 (36.00%)

20 (64.52%)

17 (77.27%)

18 (72.00%)

34 (69.39%)

pAB < 0.001#

DFF45**

 High

1 (1.11%)

0 (0.00%)

0.409

1 (3.22%)

0 (0.00%)

0 (0.00%)

2 (4.08%)

0.935

 Low

7 (7.78%)

13 (10.40%)

3 (9.68%)

2 (9.09%)

3 (12.00%)

10 (20.41%)

 Negative

82 (9.11%)

112 (89.6%)

27 (87.10%)

20 (90.91%)

22 (88.00%)

37 (75.51%)

pAB = 0.101

Bcl-2***

 High

29 (32.22%)

44 (35.20%)

0.523

2 (6.45%)

1 (4.55%)

1 (4.00%)

5 (10.21%)

0.187

4 (12.90%)

4 (18.18%)

3 (12.00%)

 Low

34 (37.78%)

38 (30.40%)

16 (32.65%)

 Negative

27 (30.00%)

43 (34.40%)

25 (80.65%)

17 (77.27%)

21 (84.00%)

28 (57.14%)

pAB < 0.001#

  1. pA – chi-squared test in Group A; pB – chi-squared test in Group B; pAB – chi-squared test between Group A and Group B; $endometrial adenocarcinoma grade 1; $$endometrial adenocarcinoma grade 2; $$$endometrial adenocarcinoma grade 3; *DFF40 – DNA fragmentation factor 40; **DFF45 – DNA fragmentation factor 45; ***BCL2 – B-cell lymphoma 2