Fig. 4

MTH1 targeting reduces H23 cell proliferative capacity. WST-1 assay on cells grown in media without transfection reagent (no siRNA), or 5 days after transfection with MTH1 siRNA or scramble siRNA. a H23. b A459. c H522. d MRC-5. (a), (b) and (d) Values from 4 independent experiments were used to generate final mean values and SD. (c) Values from 3 independent experiments were used to generate final mean values and SD. Error bars represent SD. Asterisks indicate a significant difference relative to corresponding no siRNA controls (****P < 0.0001, ***P < 0.001, **P < 0.01, *P < 0.05)