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Table 1 Breakpoints detected within the AF9 gene in BA-treated NP69 cells

From: Bile acids at neutral and acidic pH induce apoptosis and gene cleavages in nasopharyngeal epithelial cells: implications in chromosome rearrangement

BA-treated NP69 cells Breakpoint Remarks
0.5 mM BA, pH 7.4 245527 This chromosome break falls within the AF9 region (at coordinates 245,252–245,612) that was previously reported to translocate with the MLL gene leading to the formation of the MLL-AF9 fusion gene in an ALL patient [GenBank:AM050804].
245596 This chromosome break falls within the AF9 region (at coordinates 245,252–245,612) that was previously reported being involved in the formation of the MLL-AF9 fusion gene in an ALL patient. This breakpoint is three nucleotides different from that reported in cultured normal blood cells treated with VP16 (at coordinate 245,593) [74].
245979  
0.5 mM BA, pH 5.8 245621 This breakpoint is nine nucleotides different from that identified in an ALL patient (at coordinate 245,612) [GenBank:AM050804].
245708 This breakpoint is five nucleotides different from that reported in H2O2-treated NP69 cells (at coordinate 245,703) [77].
245809  
  1. The breakpoints identified within the AF9 gene were mapped according to the AF9 sequence retrieved from Ensembl database [EMBL:ENSG00000171843]