BA-treated NP69 cells | Breakpoint | Remarks |
---|---|---|
0.5 mM BA, pH 7.4 | 245527 | This chromosome break falls within the AF9 region (at coordinates 245,252–245,612) that was previously reported to translocate with the MLL gene leading to the formation of the MLL-AF9 fusion gene in an ALL patient [GenBank:AM050804]. |
245596 | This chromosome break falls within the AF9 region (at coordinates 245,252–245,612) that was previously reported being involved in the formation of the MLL-AF9 fusion gene in an ALL patient. This breakpoint is three nucleotides different from that reported in cultured normal blood cells treated with VP16 (at coordinate 245,593) [74]. | |
245979 | Â | |
0.5Â mM BA, pHÂ 5.8 | 245621 | This breakpoint is nine nucleotides different from that identified in an ALL patient (at coordinate 245,612) [GenBank:AM050804]. |
245708 | This breakpoint is five nucleotides different from that reported in H2O2-treated NP69 cells (at coordinate 245,703) [77]. | |
245809 | Â |