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Table 3 Association between hypopharyngeal and laryngeal cancers and occupational exposure to oxygenated solvents

From: Occupational exposure to petroleum-based and oxygenated solvents and hypopharyngeal and laryngeal cancer in France: the ICARE study

 

Controls

Hypopharynx

Larynx

 

n

n

ORa

[95% CI]

n

ORa

[95% CI]

Ketones and esters

 Never

2055

238

 

297

 

 Ever

618

100

1.01

[0.74–1.37]

126

1.10

[0.84–1.45]

CEI

 Low

309

46

1.05

[0.71–1.56]

62

1.24

[0.88–1.75]

 Medium

245

38

0.89

[0.58–1.35]

53

1.08

[0.74–1.56]

 High

64

16

1.34

[0.70–2.59]

11

0.87

[0.42–1.79]

 p for trend

   

0.52

  

0.62

Alcohols

 Never

1775

225

 

290

 

 Ever

898

113

0.95

[0.72–1.27]

133

0.90

[0.70–1.17]

CEI

 Low

447

45

0.85

[0.59–1.25]

64

0.99

[0.71–1.37]

 Medium

359

50

1.07

[0.74–1.55]

53

0.86

[0.60–1.22]

 High

91

17

1.25

[0.68–2.31]

16

0.93

[0.51–1.72]

 p for trend

   

0.31

  

0.87

Diethyl ether

 Never

2580

333

 

419

 

 Ever

90

5

0.59

[0.20–1.70]

4

0.37

[0.12–1.11]

CEI

 Low

45

1

0.28

[0.04–2.19]

1

0.2

[0.03–1.53]

 Medium

36

4

1.41

[0.43–4.67]

3

0.73

[0.20–2.65]

 High

9

0

0

 p for trend

   

0.90

  

0.41

Ethylene glycol

 Never

2487

312

 

387

 

 Ever

183

26

0.82

[0.49–1.36]

36

1.00

[0.64–1.56]

CEI

 Low

92

15

1.08

[0.57–2.04]

28

1.75

[1.04–2.94]

 Medium

72

11

0.83

[0.39–1.74]

6

0.39

[0.16–0.96]

 High

19

0

2

0.34

[0.07–1.64]

 p for trend

   

0.10

  

0.04

Tetrahydrofuran

 Never

2603

319

 

406

 

 Ever

67

19

1.67

[0.87–3.21]

17

1.39

[0.73–2.63]

CEI

 Low

35

7

1.33

[0.53–3.35]

9

1.50

[0.66–3.35]

 Medium

26

8

1.57

[0.61–4.08]

8

1.62

[0.65–4.07]

 High

6

4

2.63

[0.55–12.65]

0

 p for trend

   

0.07

  

0.80

  1. Abbreviations: CEI Cumulative Exposure Index
  2. aOR adjusted for age at interview, residence area, alcohol consumption, smoking status, frequency and duration of smoking, exposure to asbestos