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Table 2 Association between hypopharyngeal and laryngeal cancers and occupational exposure to petroleum-based solvents

From: Occupational exposure to petroleum-based and oxygenated solvents and hypopharyngeal and laryngeal cancer in France: the ICARE study

  Controls Hypopharynx Larynx
Petroleum based solvents n n ORa [95% CI] n ORa [95% CI]
Benzene
 Never 2120 237   314  
 Ever 552 102 1.07 [0.80–1.45] 109 0.94 [0.71–1.24]
CEI
 Low 279 51 1.15 [0.78–1.69] 46 0.81 [0.55–1.18]
 Medium 220 39 1.02 [0.67–1.57] 56 1.27 [0.87–1.84]
 High 53 12 0.9 [0.43–1.89] 7 0.42 [0.18–1.01]
 p for trend     0.98    0.21
Gasoline
 Never 2161 243   323  
 Ever 510 96 1.11 [0.83–1.50] 100 0.93 [0.70–1.23]
CEI
 Low 257 54 1.19 [0.82–1.72] 51 0.89 [0.62–1.27]
 Medium 205 32 1.02 [0.65–1.61] 46 1.19 [0.80–1.77]
 High 48 10 0.93 [0.42–2.06] 3 0.23 [0.07–0.79]
 p for trend     0.87    0.03
Special petroleum products
 Never 2439 300   384  
 Ever 234 38 1.20 [0.79–1.82] 39 0.93 [0.63–1.39]
CEI
 Low 118 18 1.22 [0.68–2.20] 17 0.86 [0.48–1.54]
 Medium 93 17 1.21 [0.65–2.24] 20 1.07 [0.61–1.89]
 High 23 3 1.10 [0.29–4.17] 2 0.64 [0.14–2.94]
 p for trend     0.55    0.75
Diesel, fuels and kerosene
 Never 1753 175   239  
 Ever 918 164 1.19 [0.90–1.56] 184 1.05 [0.82–1.35]
CEI
 Low 460 80 1.12 [0.80–1.56] 88 1.01 [0.74–1.37]
 Medium 366 69 1.36 [0.96–1.93] 80 1.21 [0.88–1.67]
 High 92 15 0.92 [0.48–1.75] 16 0.80 [0.43–1.48]
 p for trend     0.61    0.41
White spirits
 Never 1436 125   186  
 Ever 1240 216 1.14 [0.82–1.58] 237 0.93 [0.70–1.24]
CEI
 Low 620 93 1.15 [0.80–1.67] 112 0.99 [0.71–1.37]
 Medium 494 86 0.99 [0.67–1.47] 94 0.84 [0.59–1.20]
 High 126 37 1.46 [0.88–2.43] 31 0.97 [0.58–1.60]
 p for trend     0.09    0.70
  1. Abbreviations: CEI Cumulative Exposure Index
  2. aOR adjusted for age at interview, residence area, alcohol consumption, smoking status, frequency and duration of smoking, exposure to asbestos