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Fig. 5 | BMC Cancer

Fig. 5

From: BB-Cl-Amidine as a novel therapeutic for canine and feline mammary cancer via activation of the endoplasmic reticulum stress pathway

Fig. 5

DDIT3 gene expression indicates endoplasmic reticulum (ER) stress activation after treatment with BB-CLA. a Expression levels of DDIT3 and DDIT4 mRNA in canine and feline and tumoral mammary cell lines after 6 h of BB-CLA or DMSO (control) treatment as determined by qRT-PCR. **P < 0.01, ***P < 0.001. b Schematic representation of the findings presented in this study. In normal cells, baseline ER stress is low, thus any stress as a result of BB-CLA treatment is managed by the pathway at low concentrations. In tumor cells, where baseline ER stress is already high, any additional stress from BB-CLA treatment overloads the pathway leading to the initiation of cell death pathways. n = 3. Data are presented as mean ± standard deviation

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BMC Cancer

ISSN: 1471-2407

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