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Table 5 Univariate and multivariate logistic regression model for CTSK protein expression and LNM

From: Cathepsin K associates with lymph node metastasis and poor prognosis in oral squamous cell carcinoma

 

Univariate

 

OR

95% CI

p-value

pTa

1.49

1.01 - 2.20

0.044

Peri-neural invasiona

5.20

1.87–14.45

0.002

Vaso-invasiona

9.71

2.06–45.89

0.004

Depth of invasion

1.51

0.85–2.69

0.165

Spidery growth

4.44

1.41–14.00

0.011

CTSK protein expression (stroma)

4.04

1.57–10.36

0.004

CTSK protein expression (tumor)

7.65

2.51–23.32

< 0.001

 

Multivariate

CTSK protein expression (tumor)

9.46

2.83–31.65

< 0.01

corrected for pT-status

  1. Dichotomization was made into low expression (score 0–25) versus high expression (score 26–200). The most important predictive parameters (pT, peri-neural invasion, vaso-invasion, depth of invasion, spidery growth) were added in the model
  2. LNM = lymph node metastasis, OR = odds ratio, HR = hazard ratio, 95% CI = 95% confidence interval, p-value of the Cox regression model
  3. aage: < 60 vs ≥ 60 years, tumor stage I, II vs III, IV, pN status pN0 vs pN+