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Table 5 Univariate and multivariate logistic regression model for CTSK protein expression and LNM

From: Cathepsin K associates with lymph node metastasis and poor prognosis in oral squamous cell carcinoma

  Univariate
  OR 95% CI p-value
pTa 1.49 1.01 - 2.20 0.044
Peri-neural invasiona 5.20 1.87–14.45 0.002
Vaso-invasiona 9.71 2.06–45.89 0.004
Depth of invasion 1.51 0.85–2.69 0.165
Spidery growth 4.44 1.41–14.00 0.011
CTSK protein expression (stroma) 4.04 1.57–10.36 0.004
CTSK protein expression (tumor) 7.65 2.51–23.32 < 0.001
  Multivariate
CTSK protein expression (tumor) 9.46 2.83–31.65 < 0.01
corrected for pT-status
  1. Dichotomization was made into low expression (score 0–25) versus high expression (score 26–200). The most important predictive parameters (pT, peri-neural invasion, vaso-invasion, depth of invasion, spidery growth) were added in the model
  2. LNM = lymph node metastasis, OR = odds ratio, HR = hazard ratio, 95% CI = 95% confidence interval, p-value of the Cox regression model
  3. aage: < 60 vs ≥ 60 years, tumor stage I, II vs III, IV, pN status pN0 vs pN+