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Table 4 Univariate and multivariate DSS Cox regression model for gene and protein CTSK expression

From: Cathepsin K associates with lymph node metastasis and poor prognosis in oral squamous cell carcinoma

  Univariate
  HR 95% CI p-value
Agea 1.01 0.48–2.12 0.978
Tumor stageb 4.01 1.21–13.29 0.023
pNc 4.10 1.66–10.15 0.002
CTSK protein expression (stroma) 2.40 1.05–5.50 0.038
CSTK protein expression (tumor) 2.79 1.02–7.64 0.045
CTSK gene expression 2.29 1.01–5.21 0.047
  Multivariate
pN status 3.61 1.12–11.57 0.030
corrected for CTSK
protein expression (tumor)
  1. Dichotomization was made according to the cut-off values into high and low expression. The most important prognostic parameters (age, stage and pN) were added in the regression model
  2. a< 60 vs. ≥60 years; bI, II vs. III, IV; c pN0 vs. pN+