Skip to main content

Table 4 Univariate and multivariate DSS Cox regression model for gene and protein CTSK expression

From: Cathepsin K associates with lymph node metastasis and poor prognosis in oral squamous cell carcinoma

 

Univariate

 

HR

95% CI

p-value

Agea

1.01

0.48–2.12

0.978

Tumor stageb

4.01

1.21–13.29

0.023

pNc

4.10

1.66–10.15

0.002

CTSK protein expression (stroma)

2.40

1.05–5.50

0.038

CSTK protein expression (tumor)

2.79

1.02–7.64

0.045

CTSK gene expression

2.29

1.01–5.21

0.047

 

Multivariate

pN status

3.61

1.12–11.57

0.030

corrected for CTSK

protein expression (tumor)

  1. Dichotomization was made according to the cut-off values into high and low expression. The most important prognostic parameters (age, stage and pN) were added in the regression model
  2. a< 60 vs. ≥60 years; bI, II vs. III, IV; c pN0 vs. pN+