| |
CTSK
|
---|
mRNA
|
IHC tumor
|
IHC stroma
|
---|
Clinical characteristic
|
Smoking history
|
NS
|
NS
|
NS
|
Alcohol consumption
|
p < 0.01
|
NS
|
NS
|
Age
|
NS
|
NS
|
NS
|
cT status
|
NS
|
NS
|
NS
|
cN status
|
NS
|
NS
|
NS
|
Subsite
|
NS
|
NS
|
NS
|
Pathological characteristic
|
pN-status
|
p < 0.01
|
p < 0.01
|
p < 0.01
|
pT-status
|
NS
|
NS
|
NS
|
Infiltration depth
|
NS
|
NS
|
NS
|
Differentiation grade
|
NS
|
NS
|
NS
|
Vaso-invasion
|
p < 0.01
|
NS
|
NS
|
Bone-invasion
|
NS
|
NS
|
NS
|
Peri-neural invasion
|
p < 0.01
|
p < 0.01
|
NS
|
Spidery growth
|
NS
|
NS
|
NS
|
- Cases were stratified according to clinical and pathological characteristics. Smoking history was dichotomized to current smoker or ceased < 1 year versus ex-smoker (ceased > 1 year) and never smoker. Alcohol consumption was dichotomized to 1–4 or ≥ 5 U/day versus occasionally or never. Clinical and pathological nodal status (cN and pN) were dichotomized to cN0 versus cN+ and to pN0 versus pN+. Infiltration was dichotomized to < 4 mm versus ≥4 mm. Differentiation was dichotomized to well and moderate versus poor and undifferentiated. P-values represent the Mann-Whitney U test of these comparisons. IHC: immunohistochemistry; mRNA: messenger ribonucleic acid; NS: non-significant