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Fig. 7 | BMC Cancer

Fig. 7

From: RNA-Seq reveals the existence of a CDKN1C-E2F1-TP53 axis that is altered in human T-cell lymphoblastic lymphomas

Fig. 7

CDKN1C-E2F1-TP53 axis in T-LBL development. Having in mind the consequences of alterations in these genes in mouse models [11, 34], T-LBLs in our samples series might be classified into different categories. a In normal cells CDKN1C regulates E2F1 to control the expression of E2F target genes and the activity of TP53 during thymocyte development. b Decreasing of CDKN1C (due to epigenetic mechanisms and/or upregulation of specific miRNAs) could lead to proliferation, that may be favoured by overexpression of E2F1 (through downregulation of specific miRNAs). c The additional impairment of TP53 (by the combined effect of inactivating mutations, differential expression of isoforms, and/or deregulation of specific miRNAs) should lead T-cell lymphoblastic neoplasia development

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