Fig. 2

TP53 mutations and isoforms showing differential expression in our sample series of T-LBL. a Genomic representation of the TP53 gene showing the two missense mutations at exons 4 and 5 we detected in these samples. Alternative splicing of intron 9 generates p53 isoforms bearing different C-terminal domains (α, β and γ). b TP53 isoforms that showed differential levels of expression in our tumours. TAp53 isoforms include p53 (p53α), p53β and p53γ, whereas Δ133p53 isoforms include Δ133p53α, Δ133p53β and Δ133p53γ. TP53 protein domains: transactivation domains (TA), proline rich domain (PXXP), DNA binding domain (DNA BD), nuclear localization signal (NLS) and oligomerization domain (OD)