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Fig. 1 | BMC Cancer

Fig. 1

From: Oxidative stress enhances tumorigenicity and stem-like features via the activation of the Wnt/β-catenin/MYC/Sox2 axis in ALK-positive anaplastic large-cell lymphoma

Fig. 1

Oxidative stress induces the conversion of RU to RR cells. a RU cells derived from SupM2 and Karpas 299 cells were subjected to various doses of H2O2 for up to 2 days. The percent of GFP-positive cells was assessed by flow cytometry in RU cells from day 0 (the day of the treatment), day 1, and day 2. b The schematic experimental model of 0.3 mM H2O2 re-challenge treatment in RU cells derived from SupM2. c The GFP-positive cells in RU cells derived from SupM2 and Karpas 299 cells upon 0.3 mM and 0.5 mM H2O2 re-challenge treatment, respectively, at day 5. d The SRR2 luciferase activity in both RU and RR cells derived from SupM2 and Karpas 299 cells upon H2O2 re-challenge treatment at day 5. e The GFP-intensity of RU cells derived from SupM2, RU cells with H2O2 re-challenge, RR cells and RR cells with H2O2 re-challenge at day 5

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