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Fig. 1 | BMC Cancer

Fig. 1

From: ADAM-17 is a poor prognostic indicator for patients with hilar cholangiocarcinoma and is regulated by FoxM1

Fig. 1

Expression patterns of ADAM proteases in human hilar cholangiocarcinoma and non-cancerous tissues. a Normalized mRNA values of specific ADAMs in hilar cholangiocarcinoma tissues compared to non-cancerous tissues. The fold changes (y axis) are calculated as the log ratio of the relative amounts of mRNA in tumor/non-cancerous tissues. b A negative immunohistochemical control using an isotype Ig antibody. c, d, e Expression of ADAM-10 (c), ADAM-17 (d), and ADAM-28 (e) proteins in non-cancerous tissues (C1, D1, and E1) and hilar cholangiocarcinoma (C2, D2, and E2) by immunohistochemical analysis. Magnification: 200×. Graphical representation of the difference in the intensity of ADAM-10 (C3), ADAM-17 (D3), and ADAM-28 (E3) immunostaining in tumor (T) and normal (N) tissues. *P < 0.01

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BMC Cancer

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