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Table 3 Multivariate Cox regression analysis of progression-free and overall survival

From: EP3 (prostaglandin E2 receptor 3) expression is a prognostic factor for progression-free and overall survival in sporadic breast cancer

Covariate Progression-free survival Overall survival
   95 % CI      95 % CI   
Coefficient HR Lower Upper p-value Coefficient HR Lower   p-value
(B) Exp(B)     (B) Exp(B)    
age (continous, unit: 1 year) 0.008 1.009 0.99 1.02 0.254 0.04 1.04 1.02 1.06 *<0.001
pT2-4, reference category: pT1 -0.879 0.42 0.28 0.62 *<0.001 -1.17 0.31 0.19 0.52 *<0.001
pN1-3, reference category: pN0 -0.21 0.81 0.53 1.23 0.323 -0.44 0.64 0.38 1.10 0.107
ER pos, reference category: ER neg 0.52 1.69 1.08 2.63 *0.021 0.75 2.11 1.19 3.74 *0.011
PR pos, reference category: ER neg n.i.      0.56 1.75 1.03 2.98 *0.040
HER2 pos, reference category: HER2 neg n.i.      -0.57 0.57 0.31 1.04 0.067
EP3 pos, reference category: EP3 neg 0.59 1.81 1.22 2.67 *0.003 0.77 2.16 1.32 3.53 *0.002
number of samples 275      275     
number of events 108      72     
  1. HR hazard ratio, CI confidence interval, Pos positive, Neg negative, n.i. not included in multivariate model, as p>0.10 in bivariate analysis, *statistically significant (p-value < 0.05)