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Fig. 4 | BMC Cancer

Fig. 4

From: Altered monocyte differentiation and macrophage polarization patterns in patients with breast cancer

Fig. 4

Relationship between macrophage polarization patterns and breast cancer stages. The percentages of peripheral blood macrophages with neither (a) PM-2 K+CD14+ expression nor (b) PM-2 K+CD14 expression were significantly different between patients with advanced breast cancer (stages II and III) and those with early (stages 0 and I) breast cancer. In PM-2 K+CD14+ cells, the percentages of (c) M1-, (d) M2a and (e) M2b-like macrophages in patients with different breast cancer stages were not significantly different. (f) The percentages of M2c-like macrophages in the PM-2 K+CD14+ subset were significantly higher in patients with advanced breast cancer than in those with early breast cancer. In PM-2 K+CD14 cells, the percentages of (g) M1-like macrophages did not differ significantly according to breast cancer stage. The percentage of (h) M2a-like macrophages in the PM-2 K + CD14- subset was higher in patients with stage 0 than in those with stage I, and (i) M2b-like macrophages was lower in patients with stage 0 than in those with advanced breast cancer (stage II and III). (j) The percentage of M2c-like macrophages in the PM-2 K+CD14 subset was significantly higher in patients with advanced breast cancer (stages II and III) than in those with early breast cancer (stages 0 and I). *p < 0.05; **p < 0.01; ***p < 0.001

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