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Fig. 2 | BMC Cancer

Fig. 2

From: The Warburg effect in human pancreatic cancer cells triggers cachexia in athymic mice carrying the cancer cells

Fig. 2

Pancreatic cancer cell’s Warburg effect and cytokine secretion AsPC1 (a), BxPC3 (b), HPAF-2 (H), MiaPaCa2 (M), and Panc-1 (P) pancreatic cancer cells were incubated for 6 h in normoxia or hypoxia. a Glucose and lactate were determined in removed media to assess glucose consumption and lactate production by the cells. Original data were normalized with cellular protein. White bars = normoxia, black bars = hypoxia, n = 12, *P < 0.05. b Glucose transporter-1 (Glut1), hexokinase-2 (HK-II), and phosphofructokinase-1 (PFK-1) were determined by Western blot. c TNF-α, IL-1β, and IFN-γ were determined in removed media. Data were normalized by cellular protein. White bars = normoxia, black bars = hypoxia, n = 6, * P < 0.05

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