| |
CRC cases
| |
p-value
|
Non-cases
| |
p-value
|
|---|
|
2002 (N = 921)
|
2014 (N = 1330)
|
% change
| |
2002 (N = 1,125,723)
|
2014 (N = 921)
|
% change
| |
|---|
|
Low-dose aspirin
|
150 (16.3)
|
220 (16.5)
|
+ 0.2
|
< 0.001
|
113,852 (10.1)
|
156,206 (8.9)
|
−1.2
|
< 0.001
|
|
Clopidogrel
|
7 (0.8)
|
40 (3.0)
|
+ 2.2
|
< 0.001
|
4441 (0.4)
|
30,405 (1.7)
|
+ 1.3
|
< 0.001
|
|
Dipyridamole
|
8 (0.9)
|
7 (0.5)
|
−0.4
|
0.326
|
3787 (0.3)
|
4040 (0.2)
|
−0.1
|
< 0.001
|
|
Warfarin
|
29 (3.1)
|
84 (6.3)
|
+ 3.2
|
0.001
|
19,844 (1.8)
|
37,797 (2.2)
|
+ 0.4
|
< 0.001
|
|
All NSAIDs
|
68 (7.4)
|
57 (4.3)
|
−3.1
|
0.002
|
92,727 (8.2)
|
97,302 (5.5)
|
−2.7
|
< 0.001
|
|
tNSAIDs
|
60 (6.5)
|
52 (3.9)
|
−2.6
|
0.005
|
79,946 (7.1)
|
91,889 (5.2)
|
−1.9
|
< 0.001
|
|
Coxibs
|
8 (0.9)
|
6 (0.5)
|
−0.4
|
0.215
|
13,827 (1.2)
|
5655 (0.3)
|
−0.9
|
< 0.001
|
|
Insulin
|
15 (1.6)
|
40 (3.0)
|
+ 1.4
|
0.037
|
12,532 (1.1)
|
27,067 (1.5)
|
+ 0.4
|
< 0.001
|
|
Oral antidiabetics
|
36 (3.9)
|
150 (11.3)
|
+ 7.4
|
< 0.001
|
35,496 (3.2)
|
101,716 (5.8)
|
+ 2.6
|
< 0.001
|
|
Oral corticosteroids
|
23 (2.5)
|
35 (2.6)
|
+ 0.1
|
0.843
|
20,602 (1.8)
|
35,869 (2.0)
|
+ 0.2
|
< 0.001
|
|
Inhaled steroids
|
66 (7.2)
|
74 (5.6)
|
−1.6
|
0.0122
|
54,881 (4.9)
|
78,009 (4.4)
|
−0.5
|
< 0.001
|
|
Statins
|
95 (10.3)
|
493 (37.1)
|
+ 26.8
|
< 0.001
|
82,486 (7.3)
|
355,803 (20.3)
|
+ 13.0
|
< 0.001
|
|
Non-statins
|
9 (1.0)
|
7 (0.5)
|
−0.5
|
0.211
|
5192 (0.5)
|
7766 (0.4)
|
−0.1
|
0.018
|
|
Antidiarrhoeal medications
|
29 (3.1)
|
42 (3.2)
|
+ 0.1
|
0.990
|
13,101 (1.2)
|
32,378 (1.8)
|
+ 0.6
|
< 0.001
|
|
Antidepressants
|
69 (7.5)
|
149 (11.2)
|
+ 3.7
|
0.003
|
92,058 (8.2)
|
217,632 (12.4)
|
+4.2
|
< 0.001
|
|
Acetaminophen
|
150 (16.3)
|
249 (18.7)
|
+ 2.4
|
0.137
|
123,387 (11.0)
|
211,478 (12.0)
|
+ 1.0
|
< 0.001
|
|
PPIs
|
97 (10.5)
|
293 (22.0)
|
+ 11.5
|
< 0.001
|
69,225 (6.1)
|
266,005 (15.1)
|
+ 9.0
|
< 0.001
|
|
Antihypertensive medications
|
409 (44.4)
|
722 (54.3)
|
+ 9.9
|
< 0.001
|
316,728 (28.1)
|
519,072 (29.5)
|
+ 1.4
|
< 0.001
|
- Coxibs COX-2-selective inhibitors, CRC colorectal cancer, NSAIDs non-steroidal anti-inflammatory drugs, PPIs proton pump inhibitors, tNSAIDs traditional non-steroidal anti-inflammatory drugs
