Table 5 Principal drug therapies prescribed among CRC cases and non-cases in 2002 and 2014
CRC cases | p-value | Non-cases | p-value | |||||
|---|---|---|---|---|---|---|---|---|
2002 (N = 921) | 2014 (N = 1330) | % change | 2002 (N = 1,125,723) | 2014 (N = 921) | % change | |||
Low-dose aspirin | 150 (16.3) | 220 (16.5) | + 0.2 | < 0.001 | 113,852 (10.1) | 156,206 (8.9) | −1.2 | < 0.001 |
Clopidogrel | 7 (0.8) | 40 (3.0) | + 2.2 | < 0.001 | 4441 (0.4) | 30,405 (1.7) | + 1.3 | < 0.001 |
Dipyridamole | 8 (0.9) | 7 (0.5) | −0.4 | 0.326 | 3787 (0.3) | 4040 (0.2) | −0.1 | < 0.001 |
Warfarin | 29 (3.1) | 84 (6.3) | + 3.2 | 0.001 | 19,844 (1.8) | 37,797 (2.2) | + 0.4 | < 0.001 |
All NSAIDs | 68 (7.4) | 57 (4.3) | −3.1 | 0.002 | 92,727 (8.2) | 97,302 (5.5) | −2.7 | < 0.001 |
tNSAIDs | 60 (6.5) | 52 (3.9) | −2.6 | 0.005 | 79,946 (7.1) | 91,889 (5.2) | −1.9 | < 0.001 |
Coxibs | 8 (0.9) | 6 (0.5) | −0.4 | 0.215 | 13,827 (1.2) | 5655 (0.3) | −0.9 | < 0.001 |
Insulin | 15 (1.6) | 40 (3.0) | + 1.4 | 0.037 | 12,532 (1.1) | 27,067 (1.5) | + 0.4 | < 0.001 |
Oral antidiabetics | 36 (3.9) | 150 (11.3) | + 7.4 | < 0.001 | 35,496 (3.2) | 101,716 (5.8) | + 2.6 | < 0.001 |
Oral corticosteroids | 23 (2.5) | 35 (2.6) | + 0.1 | 0.843 | 20,602 (1.8) | 35,869 (2.0) | + 0.2 | < 0.001 |
Inhaled steroids | 66 (7.2) | 74 (5.6) | −1.6 | 0.0122 | 54,881 (4.9) | 78,009 (4.4) | −0.5 | < 0.001 |
Statins | 95 (10.3) | 493 (37.1) | + 26.8 | < 0.001 | 82,486 (7.3) | 355,803 (20.3) | + 13.0 | < 0.001 |
Non-statins | 9 (1.0) | 7 (0.5) | −0.5 | 0.211 | 5192 (0.5) | 7766 (0.4) | −0.1 | 0.018 |
Antidiarrhoeal medications | 29 (3.1) | 42 (3.2) | + 0.1 | 0.990 | 13,101 (1.2) | 32,378 (1.8) | + 0.6 | < 0.001 |
Antidepressants | 69 (7.5) | 149 (11.2) | + 3.7 | 0.003 | 92,058 (8.2) | 217,632 (12.4) | +4.2 | < 0.001 |
Acetaminophen | 150 (16.3) | 249 (18.7) | + 2.4 | 0.137 | 123,387 (11.0) | 211,478 (12.0) | + 1.0 | < 0.001 |
PPIs | 97 (10.5) | 293 (22.0) | + 11.5 | < 0.001 | 69,225 (6.1) | 266,005 (15.1) | + 9.0 | < 0.001 |
Antihypertensive medications | 409 (44.4) | 722 (54.3) | + 9.9 | < 0.001 | 316,728 (28.1) | 519,072 (29.5) | + 1.4 | < 0.001 |