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Table 5 Principal drug therapies prescribed among CRC cases and non-cases in 2002 and 2014

From: Trends in the contemporary incidence of colorectal cancer and patient characteristics in the United Kingdom: a population-based cohort study using The Health Improvement Network

  CRC cases   p-value Non-cases   p-value
2002 (N = 921) 2014 (N = 1330) % change   2002 (N = 1,125,723) 2014 (N = 921) % change  
Low-dose aspirin 150 (16.3) 220 (16.5) + 0.2 < 0.001 113,852 (10.1) 156,206 (8.9) −1.2 < 0.001
Clopidogrel 7 (0.8) 40 (3.0) + 2.2 < 0.001 4441 (0.4) 30,405 (1.7) + 1.3 < 0.001
Dipyridamole 8 (0.9) 7 (0.5) −0.4 0.326 3787 (0.3) 4040 (0.2) −0.1 < 0.001
Warfarin 29 (3.1) 84 (6.3) + 3.2 0.001 19,844 (1.8) 37,797 (2.2) + 0.4 < 0.001
All NSAIDs 68 (7.4) 57 (4.3) −3.1 0.002 92,727 (8.2) 97,302 (5.5) −2.7 < 0.001
tNSAIDs 60 (6.5) 52 (3.9) −2.6 0.005 79,946 (7.1) 91,889 (5.2) −1.9 < 0.001
Coxibs 8 (0.9) 6 (0.5) −0.4 0.215 13,827 (1.2) 5655 (0.3) −0.9 < 0.001
Insulin 15 (1.6) 40 (3.0) + 1.4 0.037 12,532 (1.1) 27,067 (1.5) + 0.4 < 0.001
Oral antidiabetics 36 (3.9) 150 (11.3) + 7.4 < 0.001 35,496 (3.2) 101,716 (5.8) + 2.6 < 0.001
Oral corticosteroids 23 (2.5) 35 (2.6) + 0.1 0.843 20,602 (1.8) 35,869 (2.0) + 0.2 < 0.001
Inhaled steroids 66 (7.2) 74 (5.6) −1.6 0.0122 54,881 (4.9) 78,009 (4.4) −0.5 < 0.001
Statins 95 (10.3) 493 (37.1) + 26.8 < 0.001 82,486 (7.3) 355,803 (20.3) + 13.0 < 0.001
Non-statins 9 (1.0) 7 (0.5) −0.5 0.211 5192 (0.5) 7766 (0.4) −0.1 0.018
Antidiarrhoeal medications 29 (3.1) 42 (3.2) + 0.1 0.990 13,101 (1.2) 32,378 (1.8) + 0.6 < 0.001
Antidepressants 69 (7.5) 149 (11.2) + 3.7 0.003 92,058 (8.2) 217,632 (12.4) +4.2 < 0.001
Acetaminophen 150 (16.3) 249 (18.7) + 2.4 0.137 123,387 (11.0) 211,478 (12.0) + 1.0 < 0.001
PPIs 97 (10.5) 293 (22.0) + 11.5 < 0.001 69,225 (6.1) 266,005 (15.1) + 9.0 < 0.001
Antihypertensive medications 409 (44.4) 722 (54.3) + 9.9 < 0.001 316,728 (28.1) 519,072 (29.5) + 1.4 < 0.001
  1. Coxibs COX-2-selective inhibitors, CRC colorectal cancer, NSAIDs non-steroidal anti-inflammatory drugs, PPIs proton pump inhibitors, tNSAIDs traditional non-steroidal anti-inflammatory drugs