Table 3 Gastrointestinal comorbidities, symptoms and investigative procedures among CRC cases and non-cases in 2002 and 2014
CRC cases | p-value | Non-cases | p-value | |||||
|---|---|---|---|---|---|---|---|---|
2002 (N = 921) | 2014 (N = 1330) | % change | 2002 (N = 1,125,723) | 2014 (N = 1,756,868) | % change | |||
n (%) | n (%) | n (%) | n (%) | |||||
Bleeding per rectum | 79 (8.6) | 73 (5.5) | − 3.1 | 0.004 | 22,989 (2.0) | 38,394 (2.2) | + 0.2 | < 0.001 |
Change in bowel habits | 26 (2.8) | 54 (4.1) | + 1.3 | 0.119 | 12,190 (1.1) | 29,360 (1.7) | + 0.6 | < 0.001 |
Abnormal weight loss | 19 (2.1) | 26 (2.0) | −0.1 | 0.857 | 7972 (0.7) | 20,924 (1.2) | + 0.5 | < 0.001 |
GI adenoma | 20 (2.2) | 41 (3.1) | + 0.9 | 0.191 | 5035 (0.4) | 16,565 (0.9) | + 0.5 | < 0.001 |
GORD | 48 (5.2) | 88 (6.6) | + 1.4 | 0.169 | 55,237 (4.9) | 110,752 (6.3) | + 1.4 | < 0.001 |
Complicated/uncomplicated PU | 20 (2.2) | 28 (2.1) | −0.1 | 0.915 | 13,891 (1.2) | 13,544 (0.8) | −0.4 | < 0.001 |
Complicated PU | 9 (1.0) | 23 (1.7) | + 0.7 | 0.138 | 6994 (0.6) | 9015 (0.5) | −0.1 | < 0.001 |
Uncomplicated PU | 13 (1.4) | 8 (0.6) | −0.8 | 0.049 | 7977 (0.7) | 5484 (0.3) | −0.4 | < 0.001 |
IBD | 19 (2.1) | 25 (1.9) | −0.2 | 0.700 | 26,919 (2.4) | 33,242 (1.9) | −0.5 | 0.032 |
National bowel screening programme | 34 (3.7) | 190 (14.3) | + 10.6 | < 0.001 | < 0.001 | 187,548 (10.7) | + 9.7 | < 0.001 |
Colonoscopy | 26 (2.8) | 83 (6.2) | + 3.4 | < 0.001 | 17,952 (1.6) | 73,186 (4.2) | + 2.6 | < 0.001 |
Sigmoidoscopy | 44 (4.8) | 54 (4.1) | −0.7 | 0.412 | 19,980 (1.8) | 36,673 (2.1) | + 0.3 | < 0.001 |
Barium enema | 95 (10.3) | 14 (1.1) | −9.2 | < 0.001 | 45,149 (4.0) | 9619 (0.5) | −3.5 | < 0.001 |