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Table 3 Gastrointestinal comorbidities, symptoms and investigative procedures among CRC cases and non-cases in 2002 and 2014

From: Trends in the contemporary incidence of colorectal cancer and patient characteristics in the United Kingdom: a population-based cohort study using The Health Improvement Network

  CRC cases   p-value Non-cases   p-value
2002 (N = 921) 2014 (N = 1330) % change   2002 (N = 1,125,723) 2014 (N = 1,756,868) % change  
n (%) n (%) n (%) n (%)
Bleeding per rectum 79 (8.6) 73 (5.5) − 3.1 0.004 22,989 (2.0) 38,394 (2.2) + 0.2 < 0.001
Change in bowel habits 26 (2.8) 54 (4.1) + 1.3 0.119 12,190 (1.1) 29,360 (1.7) + 0.6 < 0.001
Abnormal weight loss 19 (2.1) 26 (2.0) −0.1 0.857 7972 (0.7) 20,924 (1.2) + 0.5 < 0.001
GI adenoma 20 (2.2) 41 (3.1) + 0.9 0.191 5035 (0.4) 16,565 (0.9) + 0.5 < 0.001
GORD 48 (5.2) 88 (6.6) + 1.4 0.169 55,237 (4.9) 110,752 (6.3) + 1.4 < 0.001
Complicated/uncomplicated PU 20 (2.2) 28 (2.1) −0.1 0.915 13,891 (1.2) 13,544 (0.8) −0.4 < 0.001
Complicated PU 9 (1.0) 23 (1.7) + 0.7 0.138 6994 (0.6) 9015 (0.5) −0.1 < 0.001
Uncomplicated PU 13 (1.4) 8 (0.6) −0.8 0.049 7977 (0.7) 5484 (0.3) −0.4 < 0.001
IBD 19 (2.1) 25 (1.9) −0.2 0.700 26,919 (2.4) 33,242 (1.9) −0.5 0.032
National bowel screening programme 34 (3.7) 190 (14.3) + 10.6 < 0.001 < 0.001 187,548 (10.7) + 9.7 < 0.001
Colonoscopy 26 (2.8) 83 (6.2) + 3.4 < 0.001 17,952 (1.6) 73,186 (4.2) + 2.6 < 0.001
Sigmoidoscopy 44 (4.8) 54 (4.1) −0.7 0.412 19,980 (1.8) 36,673 (2.1) + 0.3 < 0.001
Barium enema 95 (10.3) 14 (1.1) −9.2 < 0.001 45,149 (4.0) 9619 (0.5) −3.5 < 0.001
  1. CRC colorectal cancer, GI gastrointestinal, GORD gastro-oesophageal reflux disease, IBD irritable bowel disease, PU peptic ulcer