|
CRC cases
| | |
Non-cases
| | |
---|
2002 (N = 921)
|
2014 (N = 1330)
|
% change
|
p value
|
2002 (N = 1,125,723)
|
2014 (N = 1,756,868)
|
% change
|
p value
|
---|
n (%)
|
n (%)
|
n (%)
|
n (%)
|
---|
Sex
| | | |
0.711
| | | |
< 0.001
|
Male
|
501 (54.4)
|
734 (55.2)
|
+ 0.8
| |
523,503 (46.5)
|
866,071 (49.3)
|
+ 2.8
| |
Female
|
420 (45.6)
|
596 (44.8)
|
−0.8
| |
602,220 (53.5)
|
890,797 (50.7)
|
−2.8
| |
Age at start datea (years)
| | | |
0.001
| | | |
< 0.001
|
40–49
|
32 (3.5)
|
68 (5.1)
|
+ 1.6
| |
330,063 (29.3)
|
577,167 (32.9)
|
+ 3.6
| |
50–59
|
115 (12.5)
|
215 (16.2)
|
+ 3.7
| |
305,523 (27.1)
|
464,427 (26.4)
|
−0.7
| |
60–69
|
244 (26.5)
|
334 (25.1)
|
−1.4
| |
234,955 (20.9)
|
374,036 (21.3)
|
+ 0.4
| |
70–79
|
355 (38.5)
|
421 (31.7)
|
−6.8
| |
174,098 (15.5)
|
229,621 (13.1)
|
−2.4
| |
80–89
|
175 (19.0)
|
292 (22.0)
|
+ 3.0
| |
81,084 (7.2)
|
111,617 (6.4)
|
−0.8
| |
Smoking
| | | |
< 0.001
| | | |
< 0.001
|
Non-smoker
|
393 (42.7)
|
575 (43.2)
|
+ 0.5
| |
511,656 (45.5)
|
841,369 (47.9)
|
+ 2.4
| |
Current
|
145 (15.7)
|
168 (12.6)
|
−3.1
| |
229,660 (20.4)
|
314,311 (17.9)
|
−2.5
| |
Former
|
230 (25.0)
|
580 (43.6)
|
+ 18.6
| |
190,297 (16.9)
|
577,415 (32.9)
|
+ 16
| |
Unknown
|
153 (16.6)
|
7 (0.5)
|
−16.1
| |
194,110 (17.2)
|
23,773 (1.4)
|
−15.8
| |
BMI (kg/m2)
| | | |
< 0.001
| | | |
< 0.001
|
15–19
|
23 (2.5)
|
48 (3.6)
|
+ 1.1
| |
39,966 (3.6)
|
65,177 (3.7)
|
+ 0.1
| |
20–24
|
253 (27.5)
|
316 (23.8)
|
−3.7
| |
316,584 (28.1)
|
482,255 (27.4)
|
−0.7
| |
25–29
|
298 (32.4)
|
517 (38.9)
|
+ 6.5
| |
323,628 (28.7)
|
594,699 (33.8)
|
+ 5.1
| |
≥ 30
|
116 (12.6)
|
360 (27.1)
|
+ 14.5
| |
169,036 (15.0)
|
441,310 (25.1)
|
+ 10.1
| |
Unknown
|
231 (25.1)
|
89 (6.7)
|
−18.4
| |
276,509 (24.6)
|
173,427 (9.9)
|
−14.7
| |
Polypharmacy
| | | |
< 0.001
| | | |
< 0.001
|
0–1 medications
|
517 (56.1)
|
612 (46.0)
|
−10.1
| |
792,376 (70.4)
|
1,151,402 (65.5)
|
−4.9
| |
2–4 medications
|
273 (29.6)
|
357 (26.8)
|
−2.8
| |
231,408 (20.6)
|
345,485 (19.7)
|
−0.9
| |
≥ 5 medications
|
131 (14.2)
|
361 (27.1)
|
+ 12.9
| |
101,939 (9.1)
|
259,981 (14.8)
|
+ 5.7
| |
Alcohol (u/w)
| | | |
< 0.001
| | | |
< 0.001
|
None
|
113 (12.3)
|
230 (17.3)
|
+ 5.0
| |
150,487 (13.4)
|
268,029 (15.3)
|
+ 1.9
| |
1–9
|
392 (42.6)
|
621 (46.7)
|
+4.1
| |
471,097 (41.8)
|
785,666 (44.7)
|
+ 2.9
| |
10–20
|
116 (12.6)
|
219 (16.5)
|
+ 3.9
| |
142,656 (12.7)
|
297,466 (16.9)
|
+ 4.2
| |
21–41
|
45 (4.9)
|
72 (5.4)
|
+ 0.5
| |
48,314 (4.3)
|
94,073 (5.4)
|
+ 1.1
| |
≥ 42
|
15 (1.6)
|
31 (2.3)
|
+ 0.7
| |
16,227 (1.4)
|
40,976 (2.3)
|
+ 0.9
| |
Unknown
|
240 (26.1)
|
157 (11.8)
|
−14.3
| |
296,942 (26.4)
|
270,658 (15.4)
|
−11
| |
PCP visitsb
| | | |
< 0.001
| | | |
< 0.001
|
0–4
|
374 (40.6)
|
249 (18.7)
|
−21.9
| |
622,029 (55.3)
|
582,007 (33.1)
|
−22.2
| |
5–9
|
252 (27.4)
|
319 (24.0)
|
−3.4
| |
277,673 (24.7)
|
435,570 (24.8)
|
+ 0.1
| |
10–14
|
135 (14.7)
|
242 (18.2)
|
+ 3.5
| |
121,781 (10.8)
|
291,525 (16.6)
|
+ 5.8
| |
15–19
|
79 (8.6)
|
171 (12.9)
|
+4.3
| |
54,652 (4.9)
|
177,759 (10.1)
|
+ 5.2
| |
≥ 20
|
81 (8.8)
|
349 (26.2)
|
+ 17.4
| |
49,588 (4.4)
|
270,007 (15.4)
|
+ 11
| |
Referralsb
| | | |
< 0.001
| | | |
< 0.001
|
0–1
|
636 (69.1)
|
531 (39.9)
|
−29.2
| |
920,723 (81.8)
|
929,757 (52.9)
|
−28.9
| |
2–4
|
218 (23.7)
|
380 (28.6)
|
+4.9
| |
155,781 (13.8)
|
464,696 (26.5)
|
+ 12.7
| |
5–9
|
58 (6.3)
|
279 (21.0)
|
+ 14.7
| |
41,329 (3.7)
|
261,011 (14.9)
|
+ 11.2
| |
≥ 10
|
9 (1.0)
|
140 (10.5)
|
+ 9.5
| |
7890 (0.7)
|
101,404 (5.8)
|
+ 5.1
| |
Hospitalizationsb
| | | |
< 0.001
| | | |
< 0.001
|
None
|
829 (90.0)
|
1109 (83.4)
|
−6.6
| |
1,063,618 (94.5)
|
1,557,111 (88.6)
|
−5.9
| |
1
|
57 (6.2)
|
133 (10.0)
|
+ 3.8
| |
43,745 (3.9)
|
134,083 (7.6)
|
+ 3.7
| |
2
|
23 (2.5)
|
49 (3.7)
|
+ 1.2
| |
11,974 (1.1)
|
40,510 (2.3)
|
+ 1.2
| |
≥ 3
|
12 (1.3)
|
39 (2.9)
|
+ 1.6
| |
6386 (0.6)
|
25,164 (1.4)
|
+ 0.8
| |
Townsend score
| | | |
< 0.001
| | | |
< 0.001
|
Quintile 1 (least deprived)
|
225 (24.4)
|
340 (25.6)
|
+ 1.2
| |
304,177 (27.0)
|
466,028 (26.5)
|
−0.5
| |
Quintile 2
|
183 (19.9)
|
329 (24.7)
|
+4.8
| |
253,931 (22.6)
|
394,091 (22.4)
|
−0.2
| |
Quintile 3
|
180 (19.5)
|
297 (22.3)
|
+ 2.8
| |
219,425 (19.5)
|
355,598 (20.2)
|
+ 0.7
| |
Quintile 4
|
183 (19.9)
|
185 (13.9)
|
−6.0
| |
178,640 (15.9)
|
289,718 (16.5)
|
+ 0.6
| |
Quintile 5 (most deprived)
|
98 (10.6)
|
140 (10.5)
|
−0.1
| |
117,993 (10.5)
|
191,274 (10.9)
|
+ 0.4
| |
Unknown
|
52 (5.6)
|
39 (2.9)
|
−2.7
|
0.001
|
51,557 (4.6)
|
60,159 (3.4)
|
−1.2
|
< 0.001
|
Setting
| | | | | | | | |
Urban
|
562 (61.0)
|
748 (56.2)
|
−4.8
| |
720,972 (64.0)
|
1,086,412(61.8)
|
−2.2
| |
Town
|
120 (13.0)
|
148(11.1)
|
−1.9
| |
129,017 (11.5)
|
178,340 (10.2)
|
−1.3
| |
Rural
|
58 (6.3)
|
73 (5.5)
|
−0.8
| |
76,435 (6.8)
|
98,160 (5.6)
|
−1.2
| |
Unknown
|
181 (19.7)
|
361 (27.1)
|
+ 7.4
| |
199,299 (17.7)
|
393,956 (22.4)
|
+4.7
| |
- aEntry into the study year (start date)
- bIn the year before the start date
- BMI body mass index, CRC colorectal cancer, PCP primary care practitioner, u/w units per week