CRC cases | Non-cases | |||||||
---|---|---|---|---|---|---|---|---|
2002 (N = 921) | 2014 (N = 1330) | % change | p value | 2002 (N = 1,125,723) | 2014 (N = 1,756,868) | % change | p value | |
n (%) | n (%) | n (%) | n (%) | |||||
Sex | 0.711 | < 0.001 | ||||||
Male | 501 (54.4) | 734 (55.2) | + 0.8 | 523,503 (46.5) | 866,071 (49.3) | + 2.8 | ||
Female | 420 (45.6) | 596 (44.8) | −0.8 | 602,220 (53.5) | 890,797 (50.7) | −2.8 | ||
Age at start datea (years) | 0.001 | < 0.001 | ||||||
40–49 | 32 (3.5) | 68 (5.1) | + 1.6 | 330,063 (29.3) | 577,167 (32.9) | + 3.6 | ||
50–59 | 115 (12.5) | 215 (16.2) | + 3.7 | 305,523 (27.1) | 464,427 (26.4) | −0.7 | ||
60–69 | 244 (26.5) | 334 (25.1) | −1.4 | 234,955 (20.9) | 374,036 (21.3) | + 0.4 | ||
70–79 | 355 (38.5) | 421 (31.7) | −6.8 | 174,098 (15.5) | 229,621 (13.1) | −2.4 | ||
80–89 | 175 (19.0) | 292 (22.0) | + 3.0 | 81,084 (7.2) | 111,617 (6.4) | −0.8 | ||
Smoking | < 0.001 | < 0.001 | ||||||
Non-smoker | 393 (42.7) | 575 (43.2) | + 0.5 | 511,656 (45.5) | 841,369 (47.9) | + 2.4 | ||
Current | 145 (15.7) | 168 (12.6) | −3.1 | 229,660 (20.4) | 314,311 (17.9) | −2.5 | ||
Former | 230 (25.0) | 580 (43.6) | + 18.6 | 190,297 (16.9) | 577,415 (32.9) | + 16 | ||
Unknown | 153 (16.6) | 7 (0.5) | −16.1 | 194,110 (17.2) | 23,773 (1.4) | −15.8 | ||
BMI (kg/m2) | < 0.001 | < 0.001 | ||||||
15–19 | 23 (2.5) | 48 (3.6) | + 1.1 | 39,966 (3.6) | 65,177 (3.7) | + 0.1 | ||
20–24 | 253 (27.5) | 316 (23.8) | −3.7 | 316,584 (28.1) | 482,255 (27.4) | −0.7 | ||
25–29 | 298 (32.4) | 517 (38.9) | + 6.5 | 323,628 (28.7) | 594,699 (33.8) | + 5.1 | ||
≥ 30 | 116 (12.6) | 360 (27.1) | + 14.5 | 169,036 (15.0) | 441,310 (25.1) | + 10.1 | ||
Unknown | 231 (25.1) | 89 (6.7) | −18.4 | 276,509 (24.6) | 173,427 (9.9) | −14.7 | ||
Polypharmacy | < 0.001 | < 0.001 | ||||||
0–1 medications | 517 (56.1) | 612 (46.0) | −10.1 | 792,376 (70.4) | 1,151,402 (65.5) | −4.9 | ||
2–4 medications | 273 (29.6) | 357 (26.8) | −2.8 | 231,408 (20.6) | 345,485 (19.7) | −0.9 | ||
≥ 5 medications | 131 (14.2) | 361 (27.1) | + 12.9 | 101,939 (9.1) | 259,981 (14.8) | + 5.7 | ||
Alcohol (u/w) | < 0.001 | < 0.001 | ||||||
None | 113 (12.3) | 230 (17.3) | + 5.0 | 150,487 (13.4) | 268,029 (15.3) | + 1.9 | ||
1–9 | 392 (42.6) | 621 (46.7) | +4.1 | 471,097 (41.8) | 785,666 (44.7) | + 2.9 | ||
10–20 | 116 (12.6) | 219 (16.5) | + 3.9 | 142,656 (12.7) | 297,466 (16.9) | + 4.2 | ||
21–41 | 45 (4.9) | 72 (5.4) | + 0.5 | 48,314 (4.3) | 94,073 (5.4) | + 1.1 | ||
≥ 42 | 15 (1.6) | 31 (2.3) | + 0.7 | 16,227 (1.4) | 40,976 (2.3) | + 0.9 | ||
Unknown | 240 (26.1) | 157 (11.8) | −14.3 | 296,942 (26.4) | 270,658 (15.4) | −11 | ||
PCP visitsb | < 0.001 | < 0.001 | ||||||
0–4 | 374 (40.6) | 249 (18.7) | −21.9 | 622,029 (55.3) | 582,007 (33.1) | −22.2 | ||
5–9 | 252 (27.4) | 319 (24.0) | −3.4 | 277,673 (24.7) | 435,570 (24.8) | + 0.1 | ||
10–14 | 135 (14.7) | 242 (18.2) | + 3.5 | 121,781 (10.8) | 291,525 (16.6) | + 5.8 | ||
15–19 | 79 (8.6) | 171 (12.9) | +4.3 | 54,652 (4.9) | 177,759 (10.1) | + 5.2 | ||
≥ 20 | 81 (8.8) | 349 (26.2) | + 17.4 | 49,588 (4.4) | 270,007 (15.4) | + 11 | ||
Referralsb | < 0.001 | < 0.001 | ||||||
0–1 | 636 (69.1) | 531 (39.9) | −29.2 | 920,723 (81.8) | 929,757 (52.9) | −28.9 | ||
2–4 | 218 (23.7) | 380 (28.6) | +4.9 | 155,781 (13.8) | 464,696 (26.5) | + 12.7 | ||
5–9 | 58 (6.3) | 279 (21.0) | + 14.7 | 41,329 (3.7) | 261,011 (14.9) | + 11.2 | ||
≥ 10 | 9 (1.0) | 140 (10.5) | + 9.5 | 7890 (0.7) | 101,404 (5.8) | + 5.1 | ||
Hospitalizationsb | < 0.001 | < 0.001 | ||||||
None | 829 (90.0) | 1109 (83.4) | −6.6 | 1,063,618 (94.5) | 1,557,111 (88.6) | −5.9 | ||
1 | 57 (6.2) | 133 (10.0) | + 3.8 | 43,745 (3.9) | 134,083 (7.6) | + 3.7 | ||
2 | 23 (2.5) | 49 (3.7) | + 1.2 | 11,974 (1.1) | 40,510 (2.3) | + 1.2 | ||
≥ 3 | 12 (1.3) | 39 (2.9) | + 1.6 | 6386 (0.6) | 25,164 (1.4) | + 0.8 | ||
Townsend score | < 0.001 | < 0.001 | ||||||
Quintile 1 (least deprived) | 225 (24.4) | 340 (25.6) | + 1.2 | 304,177 (27.0) | 466,028 (26.5) | −0.5 | ||
Quintile 2 | 183 (19.9) | 329 (24.7) | +4.8 | 253,931 (22.6) | 394,091 (22.4) | −0.2 | ||
Quintile 3 | 180 (19.5) | 297 (22.3) | + 2.8 | 219,425 (19.5) | 355,598 (20.2) | + 0.7 | ||
Quintile 4 | 183 (19.9) | 185 (13.9) | −6.0 | 178,640 (15.9) | 289,718 (16.5) | + 0.6 | ||
Quintile 5 (most deprived) | 98 (10.6) | 140 (10.5) | −0.1 | 117,993 (10.5) | 191,274 (10.9) | + 0.4 | ||
Unknown | 52 (5.6) | 39 (2.9) | −2.7 | 0.001 | 51,557 (4.6) | 60,159 (3.4) | −1.2 | < 0.001 |
Setting | ||||||||
Urban | 562 (61.0) | 748 (56.2) | −4.8 | 720,972 (64.0) | 1,086,412(61.8) | −2.2 | ||
Town | 120 (13.0) | 148(11.1) | −1.9 | 129,017 (11.5) | 178,340 (10.2) | −1.3 | ||
Rural | 58 (6.3) | 73 (5.5) | −0.8 | 76,435 (6.8) | 98,160 (5.6) | −1.2 | ||
Unknown | 181 (19.7) | 361 (27.1) | + 7.4 | 199,299 (17.7) | 393,956 (22.4) | +4.7 |