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Fig. 3 | BMC Cancer

Fig. 3

From: The kallikrein-Kinin system modulates the progression of colorectal liver metastases in a mouse model

Fig. 3

Effect of kinin receptor inhibition on tumor cell apoptosis in CBA mice induced with CRLM. (CTRL=control, SSR=SSR240612, FR=FR173657). Apoptotic tumor cells in CRLM tumors were visualised by immunostaining for caspase-3 (brown staining). a, c &e magnification 5×, a, d &f (corresponding insets) magnification 20×. 40 to 100 images at 20× magnification of stained tumor from each mouse were taken in a pre-determined systematic fashion. Caspase-3 positive cells were counted as a percentage of tumor area using Image ProPlus 6. SSR240612 treatment significantly increased the number of tumor cells undergoing apoptosis. Results are presented as group mean value ± SD, (*p < 0.05 compared to control), n = 6

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BMC Cancer

ISSN: 1471-2407

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