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Table 3 Univariate and multivariate regression analysis of factors associated with mortality in EMPD patients by radiation treatment

From: Survival analysis of patients with invasive extramammary Paget disease: implications of anatomic sites

 

Without radiation treatment

With radiation treatment

Variables

HR (95% CI)

p value

aHR (95% CI)

p value

HR (95% CI)

p value

aHR (95% CI)

p value

Anatomic sites

 Vulva or labial

reference

 

reference

 

reference

 

reference

 

 Skin

1.48 (1.26, 1.75)

<0.001

0.97 (0.77, 1.24)

0.833

0.80 (0.47, 1.34)

0.391

0.62 (0.24, 1.65)

0.342

 Penis or scrotum

1.10 (0.90, 1.34)

0.337

0.78 (0.56, 1.08)

0.134

0.95 (0.49, 1.84)

0.888

0.81 (0.26, 2.47)

0.709

 Vagina

1.90 (0.47, 7.71)

0.369

3.20 (1.71, 5.97)

<0.001

7.26 (3.89, 13.53)

<0.001

5.76 (2.34, 14.19)

<0.001

 Others

1.96 (1.46, 2.64)

<0.001

1.61 (1.15, 2.25)

0.005

1.03 (0.52, 2.04)

0.925

0.68 (0.27, 1.73)

0.421

Concurrent malignancy

 No

reference

 

reference

 

reference

 

reference

 

 Yes

1.56 (1.34, 1.82)

<0.001

1.14 (0.97, 1.33)

0.107

1.57 (1.01, 2.44)

0.043

1.21 (0.70, 2.07)

0.498

Tumor size

 Less than 2 cm

reference

 

reference

 

reference

 

reference

 

 More than 2 cm

1.01 (0.82, 1.24)

0.916

0.91 (0.75, 1.11)

0.337

1.61 (0.86, 3.01)

0.133

1.17 (0.54, 2.53)

0.691

Distant metastasis

 No

reference

 

reference

 

reference

 

reference

 

 Yes

3.11 (1.88, 5.14)

<0.001

3.43 (2.13, 5.52)

<0.001

2.80 (1.59, 4.92)

<0.001

2.71 (1.21, 6.10)

0.016

Surgery

 No

reference

 

reference

 

reference

 

reference

 

 Yes

0.50 (0.39, 0.65)

<0.001

0.70 (0.55, 0.89)

0.004

0.83 (0.51, 1.35)

0.455

0.88 (0.48, 1.63)

0.688

Age

1.09 (1.08, 1.10)

<0.001

1.09 (1.08, 1.10)

<0.001

1.06 (1.03, 1.09)

<0.001

1.06 (1.03, 1.09)

<0.001

Gender

 Female

reference

 

reference

 

reference

 

reference

 

 Male

1.35 (1.17, 1.56)

<0.001

1.50 (1.15,1.95)

0.003

0.81 (0.53, 1.24)

0.328

1.14 (0.47, 2.76)

0.771

Race

 White

reference

 

reference

 

reference

 

reference

 

 Black

0.69 (0.32, 1.48)

0.338

1.15 (0.45, 2.91)

0.770

0.49 (0.20, 1.22)

0.125

0.43 (0.15, 1.20)

0.108

 Others

0.82 (0.68, 0.98)

0.032

0.86 (0.71, 1.05)

0.132

0.54 (0.26, 1.14)

0.107

0.44 (0.22, 0.91)

0.026

High latitude state

 No

reference

 

reference

 

reference

 

reference

 

 Yes

1.09 (0.94, 1.26)

0.251

1.06 (0.91, 1.22)

0.456

0.70 (0.44, 1.12)

0.140

0.52 (0.30, 0.90)

0.019

  1. Unknown data for tumor size and race are not shown on the table.
  2. Boldface with italics indicates significant effect. p-value < 0.05
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