Fig. 6

Gene regulatory network distinguishing 1p/19q from IDHme Sub-network showing transcription factors with an out-degree of at least 10 and the signature genes connected to them. Genes (nodes) are colored according to gene expression log-ratios between the average expression in 1p/19q and IDHme. Nodes with labels represent transcription factors and the size of a node is proportional to its out-degree. Activating and repressing links are shown in yellow and green color, respectively, and transparency of a link is inversely proportional to the number of times the link is present across the 100 cross-validation iterations