Fig. 5

Regulatory network predictions and hub transcription factors. a Pearson correlations between predicted and measured expression of the 5113 signature genes on the test data are shown for the network utilizing only gene copy number data (CNV: dark-turquoise) and the network utilizing both gene copy number and gene expression data (CNV + EXP: light-turquoise) as predictors. Correlation values are averaged over 100 cross-validation iterations (see Methods for details). b Ranking of transcription factors by out-degree for the CNV + EXP network. Only very few transcription factors have high out-degree values (hubs), whereas the large majority shows few connections to other signature genes