Fig. 1

CNV-derived molecular subgroups of histologically classified oligodendrogliomas. Heatmap of genome-wide gene copy number log-ratios of 193 histologically classified oligodendrogliomas (columns) compared to normal brain for 17677 genes (rows); blue: deletions, gray: unchanged, red: amplifications. Chromosomes are highlighted by alternating gray and black bars to the left; chromosome midpoints are indicated by labels to the right. Oligodendroglioma subgroups were revealed by unsupervised clustering and are shown using green (1p/19q), yellow (IDHme), and red (7a10d) column coloring. Tumors of WHO grade II are labeled in light purple. WHO grade III is labeled in dark purple. Tumors with an IDH1/2 mutation are labeled in dark brown. The absence of an IDH mutation is labeled in light brown