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Table 3 Univariate and Multivariate Cox regression analysis for PFS of patients with EOC

From: GDF15 predict platinum response during first-line chemotherapy and can act as a complementary diagnostic serum biomarker with CA125 in epithelial ovarian cancer

Clinicopathologic characteristics

Univariate

P

Multivariate

P

HR

95% CI

HR

95% CI

Age, y

  ≤ 50 vs > 50

1.0268

0.668–1.578

0.901

   

FIGO stage

 I/II vs III/IV

6.528

3.808–11.190

0.0001

3.521

1.044–11.880

0.044

Tumor grade

 Low/Medium vs High

0.971

0.632–1.491

0.888

   

Histology

 Serous vs Nonserous

0.616

0.385–0.984

0.062

0.626

0.354–1.105

0.108

Residual tumor, cm

  ≤ 1 vs > 1

1.670

1.032–2.703

0.016

1.380

0.872–2.185

0.171

CA125

 Low vs High

1.327

0.864–2.037

0.176

   

GDF15

 Low vs High

2.057

1.326–3.190

0.0004

1.660

1.065–2.586

0.026

  1. HR: hazard ratio; CI: confidence interval
  2. Low/high group means lower or higher than the calculated median value of presurgerical serum GDF15 and CA125, respectively