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Table 3 Nuclear staining of Ezrin and its relation to cytological diagnosis, HPV infection and viral integration

From: Ezrin and E-cadherin expression profile in cervical cytology: a prognostic marker for tumor progression in cervical cancer

  

Nuclei positive to Ezrin

* p value

Total

< 50%

50-89%

> 90%

n

% (n)

% (n)

% (n)

Diagnosis

    

< 0.001

 Non-SIL, HPV (−)

20

20 (4)

50 (10)

30 (6)

 Non-SIL, HPV (+)

24

33 (8)

33 (8)

33 (8)

 LSIL

41

29 (12)

51 (21)

20 (8)

 HSIL

20

10 (2)

30 (6)

60 (12)

 Cervical cancer

20

10 (2)

5 (1)

85 (17)

Viral genotype

 HR-HPV

45

18 (8)

33 (15)

49 (22)

0.001

 MI HR-HPV

30

13 (4)

40 (12)

47 (14)

 MI HR + LR-HPV

8

0 (0)

25 (2)

75 (6)

 LR-HPV

20

60 (12)

35 (7)

5 (1)

 Negative

22

18 (4)

45 (10)

36 (8)

HPV Physical status

 Episomal

5

20 (1)

60 (3)

20 (1)

0.115

 Integrated

32

16 (5)

19 (6)

66 (21)

 Mixed

41

15 (6)

44 (18)

41 (17)

  1. MI Multiple infection, two or more viral types. *Chi-square test