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Table 2 Ezrin and E-cadherin expression and their relation to cytological diagnosis, HPV infection and viral integration

From: Ezrin and E-cadherin expression profile in cervical cytology: a prognostic marker for tumor progression in cervical cancer

 

Total

Ezrin expression

*p value

E-cadherin expression

 

Neg/Low

Moderate

High

Neg/Low

Moderate

High

*p value

n

% (n)

% (n)

% (n)

% (n)

% (n)

% (n)

Diagnosis

 Non-SIL, HPV (−)

20

65 (13)

35 (7)

0 (0)

< 0.001

35 (7)

35 (7)

30 (6)

< 0.001

 Non-SIL, HPV (+)

24

33 (8)

58 (14)

8 (2)

25 (6)

54 (13)

21 (5)

 LSIL

41

44 (18)

39 (16)

17 (7)

32 (13)

68 (28)

0 (0)

 HSIL

20

25 (5)

30 (6)

45 (9)

75 (15)

15 (3)

10 (2)

 Cervical cancer

20

0 (0)

30 (6)

70 (14)

95 (19)

5 (1)

0 (0)

HPV infection

 HR-HPV

45

38 (17)

40 (18)

22 (10)

< 0.001

58 (26)

38 (17)

4 (2)

< 0.001

 MI HR-HPV

30

13 (4)

43 (13)

43 (13)

60 (18)

23 (7)

17 (5)

 MI HR + LR-HPV

8

0 (0)

25 (2)

75 (6)

87 (7)

12 (1)

0 (0)

 LR-HPV

20

50 (10)

45 (9)

5 (1)

0 (0)

100 (20)

0 (0)

 Negative

22

59 (13)

32 (7)

9 (2)

41 (9)

32 (7)

27 (6)

HPV Physical status

 Episomal

5

80 (4)

20 (1)

0 (0)

0.021

60 (3)

40 (2)

0 (0)

0.366

 Integrated

32

25 (8)

28 (9)

47 (15)

72 (23)

19 (6)

9 (3)

 Mixed

41

22 (9)

49 (20)

29 (12)

51 (21)

39 (16)

10 (4)

  1. MI Multiple infection, two or more viral types. *Chi-square test