Comparisons of tumor-infiltrating lymphocyte levels and the 21-gene recurrence score in ER-positive/HER2-negative breast cancer

Table 1 Baseline characteristics

	Low TIL (N = 97)	Intermediate TIL (N = 88)	High TIL (N = 13)	P-value ^a
Age, median (range)	50 (28–75)	48 (34–74)	50 (27–73)	0.280 ^b
Histology				0.152
IDC	73 (75.3)	75 (85.2)	13 (100.0)
ILC	14 (14.4)	6 (6.8)	0 (0.0)
Others	10 (10.3)	7 (8.0)	0 (0.0)
pT stage				0.540
T1	65 (67.0)	61 (69.3)	7 (53.8)
T2	32 (33.0)	27 (30.7)	6 (46.2)
pN stage				0.286
N0	84 (86.6)	70 (79.5)	10 (76.9)
N1mi	5 (5.2)	3 (3.4)	0 (0.0)
N1	8 (8.2)	15 (17.0)	3 (23.1)
pStage				0.210
IA	55 (56.7)	50 (56.8)	6 (46.2)
IB	4 (4.2)	2 (2.3)	0 (0.0)
IIA	37 (38.1)	30 (34.1)	5 (38.5)
IIB	1 (1.0)	6 (6.8)	2 (15.4)
Nuclear grade ^c				< 0.001
1	4 (4.1)	5 (5.7)	1 (7.7)
2	79 (81.5)	56 (63.6)	1 (7.7)
3	12 (12.4)	27 (30.7)	11 (84.6)
Unknown	2 (2.0)	0 (0)	0 (0)
Histologic grade ^c				0.001
I	15 (15.5)	21 (23.9)	0 (0)
II	71 (73.2)	57 (64.8)	7 (53.8)
III	9 (9.3)	10 (11.4)	6 (46.2)
Unknown	2 (2.0)	0 (0)	0 (0)
PR ^d				0.649
Positive	81 (83.5)	76 (86.4)	10 (76.9)
Negative	16 (16.5)	12 (13.6)	3 (23.1)
Ki-67 ^c				0.506
≥ 20%	18 (18.6)	15 (17.1)	4 (30.8)
< 20%	79 (81.4)	72 (81.8)	9 (69.2)
Unknown	0 (0.0)	1 (1.1)	0 (0.0)

^aχ2 test except ^b
^bKruskal-Wallis test
^cMissing value
^dPositive, Allred score 2–8; Negative, Allred score 0–1
Data are presented as n (%)
IDC: invasive ductal carcinoma, ILC: invasive lobular carcinoma, pN stage: pathologic nodal stage, PR: progesterone receptor, pStage: pathologic stage, pT stage: pathologic tumor stage, TIL: tumor infiltrating lymphocyte

ISSN: 1471-2407