Table 2 Variables associated with time to HPV regression (multivariable interval censored accelerated failure time regression model with exponentially distributed regression times, estimates how many times shorter or longer is the time to regression in comparison to the reference category; mutually adjusted for all variables in the table)
Main analysis | Multiple biopsies allowed | Max. Pap normal after biopsy | All persons with CIN3+ removed | Only first follow-up included | |
|---|---|---|---|---|---|
Estimate (95% CI) | Estimate (95% CI) | Estimate (95% CI) | Estimate (95% CI) | Estimate (95% CI) | |
Biopsy cohort vs. baseline cohort | 0.46 [0.38;0.56] | 0.61 [0.51;0.73] | 0.41 [0.33;0.52] | 0.48 [0.40;0.59] | 0.45 [0.36;0.55] |
Age (per 5 years) | 0.94 [0.91;0.98] | 0.94 [0.91;0.97] | 0.95 [0.91;0.98] | 0.96 [0.92;0.99] | 0.95 [0.93;0.98] |
Smoking (ref = Never) | |||||
Current | 1.46 [1.22;1.74] | 1.47 [1.24;1.74] | 1.48 [1.23;1.78] | 1.44 [1.20;1.72] | 1.42 [1.22;1.78] |
Past | 1.53 [1.14;2.05] | 1.55 [1.17;2.06] | 1.43 [1.06;1.93] | 1.46 [1.09;1.96] | 1.47 [1.04;1.94] |
Unknown | 0.65 [0.42;1.02] | 0.77 [0.50;1.18] | 0.65 [0.41;1.02] | 0.69 [0.44;1.07] | 0.86 [0.40;1.85] |