Skip to main content

Table 1 Shortlist of the selected genesa

From: The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes

Associated gene

discription

DMR position

DMR Distance from TSS

DMCs number

Methylation difference (Tumor -Normal)

Gene expression (Tumor / Normal)

ratio

p-value

downstream

 Slpi

secretory leukocyte protease inhibitor

chr2: 164355520–164,355,812

+ 697

9

−33.83

408.37

0.0090

 Cela1

chymotrypsin-like elastase family, member 1

chr15: 100687184–100,687,240

+ 682

3

−31.23

71.51

0.0003

 Mst1r

macrophage stimulating 1 receptor

chr9: 107908081–107,908,516

+ 1192

13

−46.34

67.47

0.0005

 Btg2

B cell translocation gene 2

chr1: 134077506–134,077,566

+ 1591

3

−46.61

18.30

0.0050

 Fgl2

fibrinogen-like protein 2

chr5: 21373036–21,373,583

+ 366

10

−31.73

11.88

0.0002

 P2rx7

purinergic receptor P2X

chr5: 122644473–122,644,655

+ 562

4

−43.12

8.23

0.0031

 Lss

lanosterol synthase

chr10: 76532531–76,532,879

+ 904

8

−59.93

6.17

0.0000

 Grhl1

grainyhead-like 1

chr12: 24573292–24,573,626

+ 1005

3

−39.22

6.06

0.0020

 Itm2c

integral membrane protein 2c

chr1: 85895741–85,895,786

+ 1231

3

−31.78

3.91

0.0015

 Chmp6

charged multivesicular body protein 6

chr11: 119915542–119,915,667

+ 1732

6

−53.11

2.88

0.0002

 Vasp

vasodilator-stimulated phosphoprotein

chr7: 19269155–19,269,927

+ 1929

14

−40.96

2.27

0.0016

 Mmp14

matrix metallopeptidase 14

chr14: 54433543–54,434,231

+ 1939

13

−39.11

2.19

0.0012

 Marveld2

MARVEL domain containing 2

chr13: 100615630–100,615,803

+ 1143

2

−34.10

2.06

0.0238

 Pdk2

pyruvate dehydrogenase kinase, isoenzyme 2

chr11: 95039447–95,039,657

+ 1716

7

38.16

0.48

0.0034

 Extl1

exostoses-like 1

chr4: 134371099–134,371,620

+ 929

44

48.12

0.39

0.0216

 Grm8

glutamate receptor, metabotropic 8

chr6: 28133156–28,133,165

+ 1206

3

33.66

0.32

0.0016

 Ppp1r14a

protein phosphatase 1, regulatory inhibitor subunit 14A

chr7: 29291240–29,291,527

+ 1920

8

36.03

0.25

0.0052

 Snx29

sorting nexin 29

chr16: 11405750–11,405,827

+ 102

3

60.92

0.22

0.0218

 C8b

complement component 8, beta polypeptide

chr4: 104767260–104,767,325

+ 943

7

54.51

0.18

0.0066

 Igfals

insulin-like growth factor binding protein, acid labile subunit

chr17: 24880338–24,882,131

+ 1568

57

38.73

0.17

0.0003

 Adam11

a disintegrin and metallopeptidase domain 11

chr11: 102762268–102,762,503

+ 829

16

54.16

0.16

0.0002

 Cyp8b1

cytochrome P450, family 8, subfamily b, polypeptide 1

chr9: 121914943–121,915,025

+ 1279

6

63.26

0.10

0.0231

Upstream

 Ltb

lymphotoxin B

chr17: 35194367–35,194,502

−4

3

−32.55

20.94

0.0410

 Nfe2

nuclear factor, erythroid derived 2

chr15: 103259509–103,259,588

− 1105

4

−36.04

12.39

0.0045

 Hmgcr

3-hydroxy-3-methylglutaryl-coenzyme A reductase

chr13: 96671738–96,671,790

− 801

1

−30.40

4.80

0.0144

 Slc29a1

solute carrier family 29 member 1

chr17: 45600404–45,600,454

− 800

2

37.50

0.37

0.0010

 Slc17a8

solute carrier family 17

chr10: 89621306–89,622,039

−60

7

51.72

0.11

0.0142

  1. aThese genes are hit by PubMed search for the term “cancer” and whose expressions are up- or down-regulated more than 2-fold in an inverse manner compared to the methylation rates between the normal and tumor tissues. Chr: chromosome, DMR: differentially methylated region, DMC: differentially methylated cytosine, TSS: transcription start site. P-values were analyzed by Student’s t-test
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us