Fig. 1

Outline of DNA methylation status of normal and tumor liver tissues in C3H mice. a Hierarchical clustering of methylation profiles of normal and tumor tissues using 1-Peason’s correlation distance. b Horizontal bar plots showing the percentage of hyper- and hypo-DMCs in all DMCc (left) and in all CpG (right) per chromosome. c Pie charts showing percentage of DMCs in the region between − 5000 bp and TSS, exon, intron and intergenic. d Pie charts showing percentage of DMCs in CpG islands, CpG island shores (defined as 2 kb flanks of CpG islands) and other regions. e The scatter plot of DNA methylation differences of DMRs and gene expression ratios between the normal and tumor tissues. The data of 118 expressing genes with the promoter DMRs were used. The relationship between DNA methylation differences and gene expression ratios of normal and liver tumors was determined by Spearman correlation analysis. 28 DMRs whose associated genes are up- or downregulated by hypo- or hyper-DMRs more than 2-fold in tumor tissues and appear in a PubMed search for the term “cancer” were shown in square, and listed in Table 1. Triangle plots indicate other DMRs