Fig. 1From: Impact of RUNX2 on drug-resistant human pancreatic cancer cells with p53 mutationsp53-dependent cell death pathway. Upon DNA damage, p53 becomes activated through ATM-mediated phosphorylation, and transactivates pro-arrest p21WAF1 and/or 14-3-3σ as well as pro-apoptotic BAX, NOXA, PUMA and/or p53AIP1. The accumulation of these small mitochondrial proteins promotes mitochondria dysfunction followed by caspase-3 activation, and then cells undergo cell deathBack to article page